Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress.

Autor: Condic N; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Amiji H; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Patel D; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Shropshire WC; Center for Infectious Diseases, Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth Houston School of Public Health, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.; Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center McGovern Medical School, Houston, TX, USA., Lermi NO; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sabha Y; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., John B; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hanson B; Center for Infectious Diseases, Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth Houston School of Public Health, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.; Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center McGovern Medical School, Houston, TX, USA., Karras GI; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Genetics and Epigenetics Graduate Program, The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Jul 26; Vol. 385 (6707), pp. eadi3048. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1126/science.adi3048
Abstrakt: Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.
Databáze: MEDLINE
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