Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Autor:	Tehrani ZR; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Habibzadeh P; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Flinko R; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Chen H; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Abbasi A; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Yared JA; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA., Ciupe SM; Department of Mathematics, Virginia Tech, Blacksburg, Virginia, USA., Lewis GK; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sajadi MM; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Baltimore VA Medical Center, VA Maryland Health Care System, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. e30-e33.
DOI:	10.1093/infdis/jiad603
Abstrakt:	Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection. Furthermore, while the regression model explained 98% of the observed variance in anti-tetanus immunoglobulin G levels based on LLPC enzyme-linked immunospot assay, we were unable to fit the same model with anti-spike antibodies, again pointing to the lack of LLPC contribution to circulating anti-spike antibodies. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu