Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France.

Autor:	Combes JD; International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch, Lyon, France., Didelot JM; Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire Montpellier, Montpellier, France., Radenne S; Service d'Hépatologie, Hôpital de la Croix Rousse, CHU Lyon, Lyon, France., Zaegel-Faucher O; Service d'Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite, Marseille, France.; INSERM U912 (Sciences Économiques et Sociales de la Santé et Traitement de l'Information Médicale-SESSTIM), Université Aix Marseille, Marseille, France., Lesage AC; Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France., Siproudhis L; Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France.; INSERM U1241, University of Rennes 1, Rennes, France.; INPHY CIC 1414 University Hospital of Rennes, Pontchaillou, Rennes, France., Piroth L; Département d'Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France.; Institut National de la Sante et de la Recherche Medicale (INSERM), Centre d'Investigation Clinique INSERM (CIC INSERM 1432), Université de Bourgogne, Dijon, France., Marchand L; Agence nationale de recherche sur le sida et les hépatites, Maladies infectieuses émergentes (ANRS-MIE), Paris, France., Heard I; Centre National de Référence des HPV, Institut Pasteur, Paris, France.; Hôpital Tenon, AP-HP, Paris, France., Hoyeau N; Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP, Paris, France., Henno S; Service d'Anatomie et Cytologie Pathologiques, CHU Pontchaillou, Rennes, France., Darragh TM; Department of Pathology, University of California SanFrancisco, San Francisco, California, USA., Alberts CJ; International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch, Lyon, France., Clifford GM; International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch, Lyon, France., Etienney I; Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. 55-60.
DOI:	10.1093/infdis/jiad506
Abstrakt:	We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity. Competing Interests: Potential conflicts of interest. O. Z. F. received honoraria from Gilead for a presentation after the 2023 Conference on Retroviruses and Opportunistic Infections, as well as support from ViiV Healthcare for traveling to and attending the European AIDS Conference in October 2023 and the Société Française de Lutte contre le Sida conference in 2022. T. M. D. received grants/contracts from the U.S. National Cancer Institute for the ANCHOR study, central pathology review, and salary support to the University of California, San Francisco. C. J. A.'s employer received an unrestricted research grant from GSK for an investigator-initiated research project not related to this work. I. E. has received payment or honoraria from Merck Sharp & Dohme for an educational event for practitioners. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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