Differences in Rotavirus Shedding and Duration by Infant Oral Rotavirus Vaccination Status in Dhaka, Bangladesh, 2011-2014.

Autor:	Ciszewski J; Department of Epidemiology, Emory University, Atlanta, Georgia, USA., Taniuchi M; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.; Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.; Department of Civil and Environmental Engineering, University of Virginia, Charlottesville, Virginia, USA., Lee B; Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Colgate ER; Department of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Platts-Mills JA; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA., Haque R; International Centre for Diarrheal Disease Research, Dhaka, Bangladesh., Zaman K; International Centre for Diarrheal Disease Research, Dhaka, Bangladesh., Lopman B; Department of Epidemiology, Emory University, Atlanta, Georgia, USA., Petri WA Jr; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA., Kirkpatrick BD; Department of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Rogawski McQuade ET; Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Jul 25; Vol. 230 (1), pp. e75-e79.
DOI:	10.1093/infdis/jiad502
Abstrakt:	To evaluate how breakthrough rotavirus disease contributes to transmission, we examined the impact of rotavirus vaccination on fecal shedding and duration of illness. We used multivariable linear regression to analyze rotavirus quantity by RT-qPCR and duration among 184 episodes of rotavirus diarrhea positive by ELISA in the PROVIDE study. Vaccinated children had less fecal viral shedding compared to unvaccinated children (mean difference = -0.59 log copies per gram of stool; 95% confidence interval [CI], -.99 to -.19). Duration of illness was on average 0.47 days (95% CI, -.23 to 1.17 days) shorter among vaccinated children. Rotarix vaccination reduces shedding burden among breakthrough cases of rotavirus gastroenteritis. Clinical Trials Registration . NCT01375647. Competing Interests: Potential conflicts of interest. B. Lopman reports personal fees outside the submitted work from Epidemiologic Research Methods, LLC and Hillevax, Inc. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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