Resolution of Plaque Keratopathy in a Patient with Atopic Keratoconjunctivitis After Treatment with Leflunomide.
| Autor: | Park RB; Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Illinois, USA., Djalilian AR; Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, Illinois, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Dec; Vol. 32 (10), pp. 2572-2574. Date of Electronic Publication: 2024 Jul 25. |
| DOI: | 10.1080/09273948.2024.2379022 |
| Abstrakt: | Purpose: To report a case of resolution of corneal findings in a patient with atopic keratoconjunctivitis after treatment with leflunomide. Methods: Case report. Results: A 57-year-old male presented with ocular signs and symptoms consistent with severe atopic keratoconjunctivitis. His case was distinguished by impressive sub-epithelial Salzmann-like nodules in the shape of petaloid plaques in both eyes. These keratinized plaques persisted despite topical steroids, tacrolimus ointment, and routine subconjunctival triamcinolone injections. The patient was started on leflunomide 10 mg daily for seropositive rheumatoid arthritis with rapid subsequent improvement in his symptoms, vision, and keratopathy. The patient has remained stable on oral leflunomide. Conclusion: To the authors' knowledge, this is the first case report to describe rapid resolution of "plaque keratopathy" and improvement of AKC with leflunomide treatment. Further work remains to be done to elucidate the role of disease-modifying drugs in atopic keratoconjunctivitis. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|