Decreased free D-aspartate levels in the blood serum of patients with schizophrenia.

Autor:	Garofalo M; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy., De Simone G; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy., Motta Z; 'The Protein Factory 2.0', Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy., Nuzzo T; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy., De Grandis E; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health - DINOGMI, University of Genoa, Genoa, Italy., Bruno C; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health - DINOGMI, University of Genoa, Genoa, Italy.; Center of Translational and Experimental Myology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini, Genoa, Italy., Boeri S; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal, and Child Health - DINOGMI, University of Genoa, Genoa, Italy., Riccio MP; Department of Maternal and Child Health, Unità Operativa semplice di Dipartimento (UOSD) of Child and Adolescent Psychiatry, Azienda Ospedaliera Universitaria (AOU) Federico II, Naples, Italy., Pastore L; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli 'Federico II', Naples, Italy., Bravaccio C; Department of Medical and Translational Sciences, Child Neuropsychiatry, Federico II University, Napoli, Italy., Iasevoli F; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy., Salvatore F; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Centro Interuniversitario per Malattie Multigeniche e Multifattoriali e loro Modelli Animali (Federico II, Naples; Tor Vergata, Rome and 'G. D'Annunzio', Chieti-Pescara), Naples, Italy., Pollegioni L; 'The Protein Factory 2.0', Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy., Errico F; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Dipartimento di Agraria, Università degli Studi di Napoli 'Federico II', Portici, Italy., de Bartolomeis A; Section of Psychiatry, Laboratory of Translational and Molecular Psychiatry and Unit of Treatment-Resistant Psychosis, Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Medical School of Naples 'Federico II', Naples, Italy., Usiello A; CEINGE Biotecnologie Avanzate 'Franco Salvatore', Naples, Italy.; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2024 Jul 10; Vol. 15, pp. 1408175. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).
DOI:	10.3389/fpsyt.2024.1408175
Abstrakt:	Introduction: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations and divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both disorders, including abnormal NMDA and metabotropic receptor signaling. Methods: We conducted a bicentric study to assess the blood serum levels of NMDA receptors-related glutamatergic amino acids and their precursors, including L-glutamate, L-glutamine, D-aspartate, L-aspartate, L-asparagine, D-serine, L-serine and glycine, in ASD, SCZ patients and their respective control subjects. Specifically, the SCZ patients were subdivided into treatment-resistant and non-treatment-resistant SCZ patients, based on their responsivity to conventional antipsychotics. Results: D-serine and D-aspartate serum reductions were found in SCZ patients compared to controls. Conversely, no significant differences between cases and controls were found in amino acid concentrations in the two ASD cohorts analyzed. Discussion: This result further encourages future research to evaluate the predictive role of selected D-amino acids as peripheral markers for SCZ pathophysiology and diagnosis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Garofalo, De Simone, Motta, Nuzzo, De Grandis, Bruno, Boeri, Riccio, Pastore, Bravaccio, Iasevoli, Salvatore, Pollegioni, Errico, de Bartolomeis and Usiello.)
Databáze:	MEDLINE
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