Factors Associated With Hepatitis A Seropositivity at 23 Years After Childhood Vaccination.

Autor: Scobie HM; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Negus S; Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA., Stevenson T; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Bressler S; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Bruden D; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Simons BC; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Snowball M; Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA., Hofmeister MG; Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Bruce M; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., Townshend-Bulson L; Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA., Fischer M; Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, Alaska, USA., McMahon B; Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2024 Jul 18; Vol. 11 (7), pp. ofae417. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
DOI: 10.1093/ofid/ofae417
Abstrakt: We evaluated factors associated with the presence of hepatitis A virus antibodies 23 years after initiating vaccination at ages 6-15 months. Among 67 participants, 86% (42/49) of those vaccinated at ages 12-15 months and 61% (11/18) of those vaccinated at 6 months remained seropositive at 23 years. Lack of maternal antibodies at enrollment and higher initial vaccine response were independently associated with higher antibody concentrations at 23 years. Further research is needed to assess the duration of hepatitis A vaccine protection and possible need for a booster dose.
Competing Interests: Potential conflicts of interest. All authors reported having no conflicts of interest.
(Published by Oxford University Press on behalf of Infectious Diseases Society of America 2024.)
Databáze: MEDLINE
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