Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.

Autor: Qazi SU; Department of Medicine, Dow University of Health Sciences, Karachi, 74200, Pakistan., Bin Naeem MA; Department of Medicine, Allama Iqbal Medical College, Lahore, 79180, Pakistan., Umar M; Department of Medicine, Allama Iqbal Medical College, Lahore, 79180, Pakistan., Zahid MJ; Department of Surgery, Hayatabad Medical Complex, Peshawar, 25124, Pakistan., Kan Changez MI; Department of Medicine, Quetta Institute of Medical Sciences, Balochistan, 87300, Pakistan., Iqbal L; Department of Medicine, Karachi Medical & Dental College, Karachi, 74600, Pakistan., Rahman Khan Sherwani IA; Department of Medicine, East & North Hertfordshire NHS Trust, SG1 4AB, UK., Mehmood H; Department of Medicine, Allama Iqbal Medical College, Lahore, 79180, Pakistan., Abbasi AF; Department of Medicine, Dow University of Health Sciences, Karachi, 74200, Pakistan., Zahid A; Department of Surgery, Ziauddin Medical Hospital, Karachi, 74700, Pakistan., Perswani P; Department of Internal Medicine, University of California Riverside School of Medicine, CA 92521, USA., Mattumpuram J; Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Jazyk: angličtina
Zdroj: Future cardiology [Future Cardiol] 2024 Mar 11; Vol. 20 (4), pp. 221-228. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1080/14796678.2024.2352308
Abstrakt: Aim: We aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). Methods: A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF). Results: Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.
Databáze: MEDLINE
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