| Autor: |
Zhou Y; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China., Ma Y; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China., Sheng J; China Quality Mark Certification (Shandong) Co., LTD, Jinan, Shandong 250100, China., Ma Y; Hunan Bainianyiren Chinese Traditional Medical Institute Co., LTD, Changsha, Hunan 410221, China., Ding J; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China., Zhou W; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.; Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha, Hunan 410008, China. |
| Abstrakt: |
Pancreatic cancer remains a formidable challenge in oncology due to its aggressive nature and limited treatment options. The dense stroma surrounding pancreatic tumors not only provides structural support but also presents a formidable barrier to effective therapy, hindering drug penetration and immune cell infiltration. This review delves into the intricate interplay between stromal components and cancer cells, highlighting their impact on treatment resistance and prognosis. Strategies for stromal remodeling, including modulation of cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs) activation states, and targeting extracellular matrix (ECM) components, are examined for their potential to enhance drug penetration and improve therapeutic efficacy. Integration of stromal remodeling with conventional therapies, such as chemotherapy and immunotherapy, is discussed along with the emerging field of intelligent nanosystems for targeted drug delivery. This comprehensive overview underscores the importance of stromal remodeling in pancreatic cancer treatment and offers insights into promising avenues for future research and clinical translation. |
