Iris melanoma in an Australian cohort.

Autor: McGrath LA; Terrace Eye Centre, Queensland Ocular Oncology Service, Brisbane, Australia.; School of Medicine, University of Queensland, Brisbane, Australia., Warrier SK; Terrace Eye Centre, Queensland Ocular Oncology Service, Brisbane, Australia., Glasson WJ; Terrace Eye Centre, Queensland Ocular Oncology Service, Brisbane, Australia.; School of Medicine, University of Queensland, Brisbane, Australia., D'Mellow MG; Terrace Eye Centre, Queensland Ocular Oncology Service, Brisbane, Australia.; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Hamilton HR; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Palmer JM; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Brooks KM; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Johansson PA; School of Medicine, University of Queensland, Brisbane, Australia.; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Hayward NK; Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jazyk: angličtina
Zdroj: Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2024 Nov; Vol. 52 (8), pp. 880-887. Date of Electronic Publication: 2024 Jul 24.
DOI: 10.1111/ceo.14424
Abstrakt: Background: To report the clinicopathological features and epidemiology of iris melanoma in Queensland, Australia.
Methods: This was a retrospective study of 86 patients with iris melanoma treated between 2001 and 2022 at the Queensland Ocular Oncology Service, Brisbane, Australia. Main outcome measures included demographics, clinical and phenotypic features, age-adjusted incidence and relative survival.
Results: Eighty-six patients (63% female) were included. Mean age was 54 years (range 17-82 years). The majority of patients (97%) were Caucasian, with blue eyes, fair skin and Fitzpatrick Skin Type I or II. Demographic features and clinical history showed a tendency for high ultraviolet radiation (UVR) exposure in the cohort. Histopathology was available in 69 cases (82%), and of these, 77% tumours were of spindle cell origin, with low-risk genetic profiles. Patients were followed for a mean of 8 years (median 7, range 1-21 years) after diagnosis, and only one case of metastasis was documented.
Conclusions: The association of iris freckles, history of UVR exposure and dermatologic findings supports the role of UVR in iris melanoma. Occupation and avocation history, as well as evaluation of iris freckles may offer an easily accessible way of stratifying the risk of an individual for development of UVR-related uveal melanoma.
(© 2024 The Author(s). Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.)
Databáze: MEDLINE
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