Superior Tumor Cell Uptake by Mono- and Tri-Nuclear Rhodamine-Gadolinium(III) Agents.

Autor: Robertson AG; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Hall AJ; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia., Marfavi A; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.; Nano Institute, Sydney, NSW 2006, Australia., Rendina LM; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.; Nano Institute, Sydney, NSW 2006, Australia.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Oct 01; Vol. 30 (55), pp. e202402244. Date of Electronic Publication: 2024 Sep 13.
DOI: 10.1002/chem.202402244
Abstrakt: The synthesis and characterization of a novel trinuclear rhodamine-Gd(III) complex, along with two analogous mononuclear rhodamine-Gd(III) complexes, are reported. All complexes displayed good selectivity in a human glioma cell line (T98G) when compared to a glial cell line (SVG p12), with low cytotoxicities. Superior tumor cell uptake for these Gd(III) complexes was observed at lower incubation concentrations compared to previously-reported delocalized lipophilic cations such as a rhodamine-lanthanoid(III) probe and Gd(III)-arylphosphonium complexes, with ca. 150 % and 250 % increases in Gd uptake, respectively.
(© 2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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