The LATE score: A novel framework for echocardiographic evaluation of left ventricular filling pressure.

Autor: Tomlinson S; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia., Chan J; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia., Appadurai V; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia., Edwards N; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia., Savage M; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia., Lam AK; Griffith University, School of Medicine and Menzies Health Institute Queensland, Griffith Health Centre, Level 8.86, QLD 4215, Australia., Scalia GM; The Prince Charles Hospital, Department of Cardiology, 627 Rode Road, Chermside, QLD 4032, Australia. Electronic address: Gregory.Scalia@health.qld.gov.au.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2024 Oct 15; Vol. 413, pp. 132371. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1016/j.ijcard.2024.132371
Abstrakt: Background: The LATE score (LATE: Left Atrial reservoir strain (LASr), Tricuspid regurgitation maximum velocity (TR Vmax), and E/e' average) is a novel framework for echocardiographic assessment of left ventricular filling pressure (LVFP). LATE = 0 indicates normal LVFP. LATE = 1 indicates resting LVFP is borderline elevated, and the patient may be at risk of pathological elevation of LVFP during exertion. LATE ≥2 indicates LVFP is severely elevated.
Methods: The LATE score was derived from reported thresholds of LASr and conventional echocardiographic parameters for predicting LVFP. The LATE score was prospectively evaluated in a cross-sectional study of 63 patients undergoing transthoracic echocardiography immediately prior to cardiac catheterization with invasive assessment of LVFP. Accuracy of the LATE score was compared to 2016 ASE diastology algorithms.
Results: Mean patient age was 62.9 ± 13.6 years with 22% female. LATE = 0 in 29 patients, of which 24 (83%) had normal LVFP (mean LVFP 9 mmHg, SD ±3 mmHg). LATE = 1 in 23 patients, of which 11 (48%) had elevated LVFP (mean LVFP 12 mmHg, SD ± 4 mmHg). LATE was ≥2 in 11 patients, all of which had elevated LVFP (100%) (mean LVFP 16 mmHg, SD ±3 mmHg). The LATE score showed greater agreement with invasive assessment than the 2016 algorithms (LATE kappa = 0.73, 2016 kappa = 0.37).
Conclusions: The LATE score is a simple and effective tool for evaluation of LVFP that is more accurate than the 2016 algorithms. The LATE score provides insight beyond binary classification of normal versus elevated LVFP.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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