Contemporary Incidence of Cognitive Impairment or Dementia in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis.

Autor:	Lo HZ; School of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia, huizhenlo0305@gmail.com., Wee CF; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Low CE; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo YH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo YN; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yun CY; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Syn NL; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan BYQ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Chai P; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Yeo LLL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Yeo TC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Chong YF; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Poh KK; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Kong WKF; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Wong RCC; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Chan MY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore., Sia CH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2024 Jul 24, pp. 1-15. Date of Electronic Publication: 2024 Jul 24.
DOI:	10.1159/000540450
Abstrakt:	Introduction: Despite the high prevalence of cognitive impairment or dementia post-coronary artery bypass grafting (CABG), the incidence of cognitive impairment or dementia post-CABG in contemporary practice is currently unclear. Therefore, this paper aims to investigate the incidence and associated risk factors of cognitive impairment or dementia in patients' post-CABG. Methods: A systematic search across three databases (PubMed, SCOPUS, and Embase) was conducted for studies published in or after 2013 that reported cognitive impairment or dementia post-CABG. Subgroup analyses and meta-regression by risk factors were performed to determine their influence on the results. Results: This analysis included 23 studies with a total of 2,620 patients. The incidence of cognitive impairment or dementia less than 1 month, 2 to 6 months, and more than 12 months post-CABG was 35.96% (95% confidence interval [CI]: 28.22-44.51, I2 = 87%), 21.33% (95% CI: 13.44-32.15, I2 = 88%), and 39.13% (95% CI: 21.72-58.84, I2 = 84%), respectively. Meta-regression revealed that studies with more than 80% of the cohort diagnosed with hypertension were significantly associated with incidence of cognitive impairment or dementia less than 1 month post-CABG. Conclusion: This meta-analysis demonstrates a high incidence of cognitive impairment or dementia in patients' post-CABG in contemporary practice, particularly less than 1 month post-CABG and more than 12 months post-CABG. We found that hypertension was a significant risk factor in the short-term (less than 1 month) follow-up period for cognitive impairment or dementia post-CABG. Future research should be done to assess strategies to reduce cognitive impairment post-CABG. (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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