Research progress on pathogenesis of chronic fatigue syndrome and treatment of traditional Chinese and Western medicine.

Autor: Liu T; Heilongjiang University of Chinese Medicine, Harbin, China., Sun W; Harbin Medical University, Harbin, China., Guo S; Heilongjiang University of Chinese Medicine, Harbin, China., Chen T; Heilongjiang University of Chinese Medicine, Harbin, China., Zhu M; Heilongjiang University of Chinese Medicine, Harbin, China., Yuan Z; Heilongjiang University of Chinese Medicine, Harbin, China., Li B; Heilongjiang University of Chinese Medicine, Harbin, China., Lu J; Heilongjiang University of Chinese Medicine, Harbin, China., Shao Y; Heilongjiang University of Chinese Medicine, Harbin, China., Qu Y; Heilongjiang University of Chinese Medicine, Harbin, China., Sun Z; Heilongjiang University of Chinese Medicine, Harbin, China., Feng C; Heilongjiang University of Chinese Medicine, Harbin, China; Rehabilitation Medicine Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China; Key Laboratory of Chinese Medicine Informotics in Heilongjiang Province, 24 Heping Road, Harbin, China., Yang T; Heilongjiang University of Chinese Medicine, Harbin, China; Rehabilitation Medicine Department, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China; Key Laboratory of Chinese Medicine Informotics in Heilongjiang Province, 24 Heping Road, Harbin, China. Electronic address: 958218699@qq.com.
Jazyk: angličtina
Zdroj: Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Oct; Vol. 255, pp. 103198. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1016/j.autneu.2024.103198
Abstrakt: Chronic Fatigue Syndrome (CFS) is a complex and perplexing medical disorder primarily characterized by persistent and debilitating fatigue, often accompanied by a constellation of symptoms, including weakness, dyspnea, arthromyalgia, sore throat, and disrupted sleep patterns. CFS is defined by its persistent or recurrent manifestation for a minimum duration of six months, marked by an enduring and unrelenting fatigue that remains refractory to rest. In recent decades, this condition has garnered significant attention within the medical community. While the precise etiology of CFS remains elusive, it is postulated to be multifactorial. CFS is potentially associated with various contributory factors such as infections, chronic stress, genetic predisposition, immune dysregulation, and psychosocial influences. The pathophysiological underpinnings of CFS encompass viral infections, immune system dysregulation, neuroendocrine aberrations, heightened oxidative stress, and perturbations in gut microbiota. Presently, clinical management predominantly relies on pharmaceutical interventions or singular therapeutic modalities, offering alleviation of specific symptoms but exhibiting inherent limitations. Traditional Chinese Medicine (TCM) interventions have emerged as a promising paradigm, demonstrating notable efficacy through their multimodal, multi-target, multi-pathway approach, and holistic regulatory mechanisms. These interventions effectively address the lacunae in contemporary medical interventions. This comprehensive review synthesizes recent advancements in the understanding of the etiological factors, pathophysiological mechanisms, and interventional strategies for CFS, drawing from a corpus of domestic and international literature. Its aim is to furnish valuable insights for clinicians actively involved in diagnosing and treating CFS, as well as for pharmaceutical researchers delving into innovative drug development pathways. Moreover, it seeks to address the intricate challenges confronted by clinical practitioners in managing this incapacitating condition.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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