Effect of laparoscopic cholecystectomy on 25-hydroxyvitamin D levels and bone mineral density in post menopausal women.
| Autor: | Sharma K; Department of General Surgery, PGIMER, Chandigarh, India., Sakaray YR; Department of General Surgery, PGIMER, Chandigarh, India., S N S; Department of General Surgery, PGIMER, Chandigarh, India., Tandup C; Department of General Surgery, PGIMER, Chandigarh, India., Khare S; Department of General Surgery, PGIMER, Chandigarh, India., Savlania A; Department of General Surgery, PGIMER, Chandigarh, India., Gupta A; Department of General Surgery, AIMS, Mohali, India., Bhujade H; Department of Radiology, PGIMER, Chandigarh, India., Ram S; Biochemistry, PGIMER Chandigarh, India., Kaman L; Department of General Surgery, PGIMER, Chandigarh, India. |
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| Jazyk: | angličtina |
| Zdroj: | Acta chirurgica Belgica [Acta Chir Belg] 2024 Jul 31, pp. 1-4. Date of Electronic Publication: 2024 Jul 31. |
| DOI: | 10.1080/00015458.2024.2384687 |
| Abstrakt: | Background: Laparoscopic cholecystectomy (LC) is the gold standard management for benign gallbladder diseases. It has been observed that there is alteration in vitamin D levels and bone mineral density after cholecystectomy due to altered enterohepatic circulation. With increase in average age expectancy of the population, low levels of vitamin D levels and osteoporosis after cholecystectomies might cause increased health care burden. Methods: A prospective observational study was planned between 1 January 2022 and 30 June 2023 in the Department of General Surgery at PGIMER Chandigarh, a tertiary care hospital in north India. One hundred and three post-menopausal women who underwent LC and met the inclusion and exclusion criteria were included in the study. All participants underwent estimation of vitamin D and bone mineral density preoperatively and third-post operative month (POM). Results: The mean age of the patients was 58.46 ± 7.44. Pain abdomen was present in 68(66%) patients, 18 had epigastric discomfort and 17 had dyspepsia. The mean levels of vitamin D decreased from 21.92 at the baseline to 20.12 at third POM ( p < .001). There was a significant change in t score Femoral Neck (-1.12 vs -1.15, p < .001) and Lumbar spine L1-L4 - 1.98 vs -1.98 ( p = .033). z -scores of the femoral neck were -0.34 vs -0.54 ( p < .001) and of lumbar spine L1-L4 were -0.95 vs 1.02 ( p < .001). The decrease in fracture risk for the femoral neck ( p = .344) and the lumbar spine ( p = .223) was not statistically significant. Conclusion: There is a significant decrease in vitamin D and BMD levels after LC in post-menopausal females. |
| Databáze: | MEDLINE |
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