Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats.

Autor:	Costa CSD; Universidade Federal Fluminense - Programa de Pós-graduação em Medicina Veterinária Clínica e Reprodução Animal - Niterói (RJ), Brazil., Jorge SDF; Centro Universitário Serra dos Órgãos - Curso de Graduação em Medicina Veterinária - Teresópolis (RJ), Brazil., Figueiredo MA; Universidade Federal Fluminense - Programa de Pós-graduação em Medicina Veterinária Clínica e Reprodução Animal - Niterói (RJ), Brazil., Neves DR; Centro Universitário Serra dos Órgãos - Curso de Graduação em Medicina Veterinária - Teresópolis (RJ), Brazil., Chagas MA; Universidade Federal Fluminense - Programa de Pós-graduação em Medicina Veterinária Clínica e Reprodução Animal - Niterói (RJ), Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2024 Jul 22; Vol. 39, pp. e393024. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024).
DOI:	10.1590/acb393024
Abstrakt:	Purpose: To test the use of rainbow trout skin as a surgical mesh in abdominal hernioplasties in rats. Methods: The experiment involved 20 Wistar rats receiving implants of trout skin processed for disinfection in 0.5% glutaraldehyde and preserved in 100% glycerin. The animals were divided into four groups, divided at 7, 15, 30, and 90 days postoperatively. Clinical and infrared thermography evaluations were performed, and after euthanasia, assessments of adhesion formations and sample collection for histological evaluation were conducted. Results: The implant was observed to be intact, ensuring the integrity of the abdominal wall, support for the viscera, and normal mobility for the rats for up to 90 days. Low rates of clinical alterations were observed, with an intense inflammatory reaction up to day 7, chronic inflammation and the onset of angiogenesis at day 15, and a low inflammatory reaction with collagenous infiltrate and fibrosis at day 30. At day 90, the implants showed a collagenous and fibrotic infiltrate with a minimal inflammatory infiltrate. Conclusions: The surgical mesh of trout skin performed well, making it a potential alternative for surgical procedures in muscle aponeurotic corrections in the abdominal wall.
Databáze:	MEDLINE
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