| Autor: |
Soares THM; Programa de Pós-Graduação em Cirurgia, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil., Moraes NHL; Universidade Católica de Pernambuco, Escola de Saúde e Ciências da Vida, Rua do Príncipe, 526, Boa Vista, 50050-900 Recife, PE, Brazil., Soares KPND; Universidade Federal de Pernambuco, Unidade Multiprofissional dos Hospital das Clínicas, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil., Carvalho MM; Programa de Pós-Graduação em Cirurgia, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil., Holanda ASS; Faculdade Pernambucana de Saúde, Departamento de Educação Física, Avenida Marechal Mascarenhas de Moraes, 4861, Imbiribeira, 51150-000 Recife, PE, Brazil., Rodrigues LFS; Universidade Federal de Pernambuco, Departamento de Educação Física, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50730-120 Recife, PE, Brazil., Silva MEP; Universidade Federal de Pernambuco, Departamento de Educação Física, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50730-120 Recife, PE, Brazil., Carvalho PRC; Universidade Federal de Pernambuco, Departamento de Educação Física, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50730-120 Recife, PE, Brazil. |
| Abstrakt: |
The aim of this study is to identify the factors associated with mortality in patients with COVID-19 undergoing invasive mechanical ventilation at a university hospital in Northeastern Brazil. This is a retrospective cohort from April to August 2020 through an analysis of medical records, considering the demographic profile, comorbidities, complications, supports, respiratory and laboratory parameters. A total of 65 patients required invasive mechanical ventilation, of which 64.6% died in the ICU. They were older, had more comorbidities, shorter length of stay in the intensive care unit, received more support such as palliative care and two vasopressors simultaneously, showed lower levels of pH, hemoglobin and calcium, and higher levels of bicarbonate, lactate, prothrombin time, international normalized ratio, troponin and ferritin at the start of invasive mechanical ventilation. Furthermore, the time course of pH, arterial oxygen partial pressure to fractional inspired oxygen ratio, arterial carbon dioxide partial pressure, lactate, hemoglobin, platelets, lymphocytes, neutrophil-to-lymphocyte ratio, coagulation parameters, calcium, urea, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, ferritin, static compliance, airway resistance, tidal volume, and noradrenaline doses showed association with mortality. There was a high mortality rate in invasively mechanically ventilated COVID-19 patients, with some associated factors identified at the start of invasive mechanical ventilation and others identified over time. |
