A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression.

Autor: Firatligil FB; nkara Etlik City Hospital, Department of Obstetrics and Gynecology, Division of Perinatology - Ankara, Turkey., Yildirir BF; Tampere University, Faculty of Engineering and Natural Sciences - Tampere, Finland.; Izmir Institute of Technology, Department of Molecular Biology and Genetics - Izmir, Turkey., Yalcin-Ozuysal O; Izmir Institute of Technology, Department of Molecular Biology and Genetics - Izmir, Turkey.
Jazyk: angličtina
Zdroj: Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2024 Jul 19; Vol. 70 (6), pp. e20231673. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).
DOI: 10.1590/1806-9282.20231673
Abstrakt: Objective: Investigating the potential role of CYR61 in recurrent pregnancy loss is critical for developing diagnostic approaches and treatments for recurrent pregnancy loss.
Methods: In this prospective case-control study, we have investigated the expression patterns of CYR61 in blood samples from participants with recurrent pregnancy loss in their medical history and control group (n=20 vs n=10). Peripheral blood mononuclear cells from study and control groups were isolated and the expression patterns of the CYR61 gene were determined by real-time semi-quantitative reverse transcriptase PCR.
Results: A significant decrease in CYR61 gene expression was demonstrated in patients with two or more clinically recognized miscarriages compared with patients without miscarriages or with a history of miscarriage (p<0.01), which may make the CYR61 gene a potential candidate for predicting the risk of recurrent pregnancy loss.
Discussion: This study provides a basis for a detailed investigation of candidate biomarkers and molecular players involved in the development of recurrent pregnancy loss and for the development of potential treatment approaches to prevent recurrent pregnancy loss.
Databáze: MEDLINE
Externí odkaz: