Association between thyroid hormone resistance and obesity: a cross-sectional study and mouse stimulation test.

Autor: Wang Z; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China., Yu H; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China., Wang K; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China., Han J; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China., Song Y; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Disease, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China.; Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Aug; Vol. 32 (8), pp. 1483-1493.
DOI: 10.1002/oby.24084
Abstrakt: Objective: Thyroid hormone influences key metabolic pathways, and reduced sensitivity to thyroid hormone is considered a new risk factor for adverse metabolic outcomes. However, the association between thyroid hormone resistance and obesity in euthyroid individuals is still unknown.
Methods: We enrolled 8021 euthyroid individuals, calculated thyroid hormone resistance indices, and analyzed the association between thyroid hormone resistance and obesity by regression analysis. Furthermore, we conducted the thyrotropin-releasing hormone stimulation test in both control and obese mice (n = 5) to demonstrate the association.
Results: The euthyroid adults with overweight and obesity had increased thyroid hormone resistance indices (all p < 0.05). BMI and prevalence of overweight and obesity increased (odds ratio of thyroid feedback quantile-based index [OR TFQI ] = 1.164, p = 0.036; OR of free triiodothyronine/free thyroxine [OR FT3/FT4 ] = 1.508, p < 0.001) following the elevation of thyroid hormone resistance indices. Mediation analysis indicated a complete mediation effect (beta coefficient of indirect effect [β Ind ]= 6.838, p < 0.001) of metabolic disorders in the relationship. Furthermore, in the mice with obesity, the thyrotropin response to thyrotropin-releasing hormone stimulation (68.33-90.89 pg/mL) was comparatively blunted (p = 0.029).
Conclusions: Euthyroid individuals with obesity exhibit both central and peripheral thyroid hormone resistance, a phenomenon that is more pronounced in individuals with metabolic abnormalities. Thyroid hormone resistance is associated with an increased prevalence of overweight and obesity mediated by metabolic disorders.
(© 2024 The Obesity Society.)
Databáze: MEDLINE
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