Cognitive inflexibility moderates the relationship between relief-driven drinking motives and alcohol use.

Autor:	Piccoli LR; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Albertella L; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Christensen E; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Fontenelle LF; Institute of Psychiatry of the Federal University of Rio de Janeiro, Brazil.; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil., Suo C; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Richardson K; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia., Yücel M; Department of Psychiatry, School of Clinical Sciences, Monash University, Australia.; QIMR Berghofer Medical Research Institute, Australia., Lee RSC; BrainPark, Monash Biomedical Imaging, The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.; The Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Jazyk:	angličtina
Zdroj:	Addictive behaviors reports [Addict Behav Rep] 2024 Jun 27; Vol. 20, pp. 100559. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024).
DOI:	10.1016/j.abrep.2024.100559
Abstrakt:	Introduction: Drinking motives and neurocognition play significant roles in predicting alcohol use. There is limited research examining how relief-driven drinking motives interact with neurocognition in alcohol use, which would help to elucidate the neurocognitive-motivational profiles most susceptible to harmful drinking. This study investigated the interactions between neurocognition (response inhibition and cognitive flexibility) and relief-driven drinking, in predicting problem drinking. Methods: Participants completed the Alcohol Use Disorders Identification Test - Consumption items (AUDIT-C) to measure drinking behaviour, and online cognitive tasks, including the Value-Modulated Attentional Capture and Reversal Task (VMAC-R) and the Stop Signal Task (SST). The sample ( N  = 368) were individuals who drink alcohol, which included a subsample ( N  = 52) with problematic drinking, as defined by self-identifying as having a primary drinking problem. Drinking motives were assessed using a binary coping question in the overall sample, and the Habit, Reward, and Fear Scale (HRFS) in the subsample. Moderation analyses were conducted to investigate whether cognitive flexibility and response inhibition moderated relationships between relief-driven motives and drinking. Results: Cognitive flexibility moderated the relationship between relief-driven motives and drinking (overall sample: β = 13.69, p  = 0.017; subsample: β = 1.45, p  = 0.013). Greater relief-driven motives were associated with heavier drinking for individuals with low cognitive flexibility. There was no significant interaction between response inhibition and relief-driven motives. Conclusions: Relief-driven drinking motives interact with cognitive inflexibility to drive heavier drinking. Greater understanding of these neurocognitive-motivational mechanisms may help to develop more targeted and effective interventions for reducing harmful drinking. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Lara Piccoli is supported by an Australian Government Research Training Program PhD Scholarship. Rico Lee has received funding from the NHMRC Investigator Grant funded by the Medical Research Future Fund [APP1193946]. Murat Yücel has received funding from government funding bodies such as the NHMRC, Australian Research Council (ARC), Australian Defence Science and Technology (DST), the Department of Industry, Innovation, and Science (DIIS), the National Institutes of Health (NIH, USA); philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation; sponsored investigator-initiated trials including Incannex Healthcare Ltd. Murat also sits on the Advisory Boards of: Centre of The Urban Mental Health, University of Amsterdam; and Enosis Therapeutics. The above funding sources have had no role in the present study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit this paper for publication. (© 2024 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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