Factors Associated With Mosaicism in Human Embryos: A Retrospective Study.

Autor:	Nguyen LN; Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, VNM., Tran HP; Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, VNM., Do VN; Medical Genetics Department, Hung Vuong Hospital, Ho Chi Minh City, VNM., Ly LT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, VNM., Hoang TT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh City, VNM.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 23; Vol. 16 (6), pp. e62967. Date of Electronic Publication: 2024 Jun 23 (Print Publication: 2024).
DOI:	10.7759/cureus.62967
Abstrakt:	Objective This study aims to identify factors associated with mosaicism in human embryos at Hung Vuong Hospital. Methods We performed a retrospective analysis of data from 2018 to 2022, approved by the Hung Vuong Hospital Ethics Committee (CS/HV/23/15). We analyzed variables such as demographic characteristics, clinical measurements, and in-vitro fertilization (IVF) cycle outcomes to investigate their relationship with embryo mosaicism. Results A total of 73 couples undergoing IVF with preimplantation genetic testing (PGT) were included in the analysis. Among 308 embryos, 98 (31.8%) were mosaic, 124 (40.3%) were euploid, and 86 (27.9%) were aneuploid. Univariable analysis revealed that female age was significantly associated with increased odds of mosaicism (odd ratio (OR) = 1.11, 95% confidence interval (CI): 1.04 - 1.19, p = 0.003). Male age demonstrated a marginal association with mosaicism (OR = 1.05, 95% CI: 1.00 - 1.11, p = 0.07). Other factors, including body mass index (BMI), anti-Mullerian hormone (AMH) levels, blood types, and sperm quality, were not significantly associated with mosaicism. In the multivariable analysis, controlling for both female and male age, female age showed a trend toward significance (OR = 1.12, 95% CI: 1.02 - 1.23, p = 0.02), while male age showed no significant effect (OR = 0.99, 95% CI: 0.92 - 1.06, p = 0.75). Conclusions The findings suggest that female age is a critical factor influencing the occurrence of mosaicism in embryos. Further research is needed to fully understand the mechanisms underlying mosaicism in human embryos. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Hung Vuong Hospital Ethics Committee issued approval CS/HV/23/15. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Nguyen et al.)
Databáze:	MEDLINE
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