Paws and Pathogens: A Multidisciplinary Approach Through Bartonella henselae Endocarditis and Hepatosplenic T-Cell Lymphoma.

Autor:	Sulaiman ZI; Division of Infectious Diseases, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Schwade M; Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Raposa JT; Division of Infectious Diseases, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Desai S; Division of Hematology and Medical Oncology, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Mohan G; Division of Cardiology, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Schafer PE; Division of Cardiology, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA., Huggett AL; Division of Infectious Diseases, Department of Medicine, Medical College of Georgia, Wellstar MCG Health, Augusta, GA, USA.
Jazyk:	angličtina
Zdroj:	Journal of investigative medicine high impact case reports [J Investig Med High Impact Case Rep] 2024 Jan-Dec; Vol. 12, pp. 23247096241262718.
DOI:	10.1177/23247096241262718
Abstrakt:	Bartonella species are gram-negative coccobacilli that are globally recognized as significant pathogens causing zoonotic infections. Among Bartonella species, B. henselae, B. quintana , and B. bacilliformis are prominent pathogens causing infections in humans, often manifesting as infective endocarditis. Bartonella endocarditis can pose diagnostic challenges due to its indolent presentation and limitations of standard microbiological culture techniques to identify the organism. We report a case of a 23-year-old male, who initially presented with the manifestations of hepatosplenic T-cell lymphoma, later diagnosed with blood culture-negative endocarditis caused by B. henselae . The patient had a complicated clinical course including pancytopenia, hepatosplenomegaly, and severe aortic valve regurgitation. Despite negative blood cultures, diagnostic clues included persistent fevers and bicuspid aortic valve with abscess. High Bartonella IgG titers (>1:800) supported the diagnosis. This case underscores the importance of considering Bartonella species in patients with suspected endocarditis, particularly in those with predisposing factors and negative blood cultures. Diagnosis relies heavily on serologic assays due to low sensitivity of conventional culture methods. Treatment involves a multidisciplinary approach with antibiotics and surgical intervention for optimal outcomes. Timely recognition and management are crucial to mitigate the high mortality associated with Bartonella endocarditis, and we hope this article offers insight for clinicians. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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