| Autor: |
Wang Y; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn., Xu Y; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn., Zhang R; Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China. wangshaowei@sxmu.edu.cn., Li J; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn., Cong Y; School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R China., Li R; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn., Wang X; School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, P.R China., Shi H; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn., Wang S; Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China. wangshaowei@sxmu.edu.cn., Feng L; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P.R. China. hshi@sxu.edu.cn.; Institute for Carbon-Based Thin Film Electronics, Peking University, Shanxi (ICTFE-PKU), Taiyuan 030012, China. |
| Abstrakt: |
Sonodynamic therapy (SDT) is a promising strategy to treat deep-seated bacterial infections with good tissue penetration and spatiotemporal controllability. However, the low ROS generation efficiency of current sonosensitizers limits the development of SDT. Herein, we report a porphyrin derivative, TAPyPP-2, the sonodynamic activity of which is enhanced with less oxygen dependence by tuning its molecular assembly behavior. TAPyPP-2 can spontaneously form an ultra-small nano-assembly with a diameter of 6 nm in water by conjugation with primary amine salt-decorated pyridinium via π-π staking. The ultra-small assembly behavior can lower the energy gap between singlet and triplet states to 0.01 eV and promote the separation of holes and electrons, which facilitates ROS generation under ultrasound irradiation, in particular type I ROS. The unique hydrophilic ratio and positive charges endow TAPyPP-2 with superior abilities to interact with Staphylococcus aureus , resulting in extremely high sonodynamic antibacterial activity. Therefore, TAPyPP-2 successfully kills Staphylococcus aureus bacteria in the enclosed cavity of synovial joint and achieves effective SDT of septic arthritis. This work is anticipated to motivate enormous interest in the development of efficient SDT. |
