Comparison of therapeutic agents' short-term effects on facial and scalp actinic keratosis: A network meta-analysis.

Autor: Gupta AK; Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Mediprobe Research Inc., London, Ontario, Canada., Bamimore MA; Mediprobe Research Inc., London, Ontario, Canada., Wang T; Mediprobe Research Inc., London, Ontario, Canada., Polla Ravi S; Mediprobe Research Inc., London, Ontario, Canada., Haas-Neil S; Mediprobe Research Inc., London, Ontario, Canada., Martin G; George Martin Dermatology Associates, Kihei, Hawaii, USA., Piguet V; Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Dermatology, Women's College Hospital, Toronto, Ontario, Canada., Talukder M; School of Pharmacy, BRAC University, Dhaka, Bangladesh.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 Nov; Vol. 23 (11), pp. 3654-3661. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1111/jocd.16475
Abstrakt: Background: Care for actinic keratosis (AK) can be improved with more knowledge on the relative of effect of indicated therapies.
Objectives: Using network meta-analyses, we quantitatively determined the comparative "short-term" effects of interventions in adults with facial and scalp AK.
Methods: On February 28, 2023, evidence from the peer-reviewed literature was systematically obtained from OVID, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov. We analyzed data from studies published in English, of a trial design, and investigating the effect of an actinic keratosis monotherapy. Patient complete clearance, patient partial clearance or lesion-specific clearance across adults were analyzed at 8-12 weeks after therapy. Patient complete clearance pertained to proportion of participants who experienced complete clearance of actinic keratosis lesions; patient partial clearance corresponded to percentage of subjects who achieved at least 75% clearance of actinic keratosis lesions; lesion-specific clearance represented the percentage of all lesions that were cleared. In the main (i.e., base) analyses, nodes were analyzed only at the level of the agent.
Results: Data from a total of 84 studies were used-across which 22 active agents were identified. Estimates of interventions' surface under the cumulative ranking curve rankings and (pairwise) relative effects were estimated. Across the three outcomes, fluorouracil 5% was ranked the most effective.
Conclusions: Our work is the first to provide information on covariate-adjusted relative effects of actinic keratosis therapies- including the more recently reported treatments-for the face and scalp; this knowledge may help physicians and patients make more informed decisions.
(© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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