Medicinal cannabis tea contains variable doses of cannabinoids and no terpenes.

Autor: Sønderskov MB; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Hasselstrøm JB; Department of Forensic Medicine, Aarhus University, Aarhus N, Denmark., Bahij R; Department of Green Technology, University of Southern Denmark, Odense M, Denmark., Andersen CU; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.; Department of Forensic Medicine, Aarhus University, Aarhus N, Denmark.
Jazyk: angličtina
Zdroj: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Sep; Vol. 135 (3), pp. 334-344. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1111/bcpt.14056
Abstrakt: Tea is a recommended way of administration of prescribed cannabis plant products in Denmark. We aimed to investigate the cannabinoid and terpene doses contained in different teas. We analysed tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and terpene concentrations in three repeated preparations of each type of tea, and in plant material. In standard tea, concentrations of THC were [median (min-max)] 9.5 (2.3-15), 19 (13-34), and 36 (26-57) μg/mL for products with a labelled content of 6.3%, 14%, and 22% total THC (THC + THCA), respectively. The CBD concentration in tea from a product labelled with 8% total CBD (CBD + CBDA) was 7.5 (1.9-10) μg/mL. Based on this, the recommended starting amount of 0.2 L of the different teas would contain between 0.46 and 11.3 mg THC, and 0.38 to 2.0 mg CBD. Adding creamer before, but not after boiling, increased the THC and CBD concentration 2.3-4.4 and 2.1-fold, respectively. Terpenes were detected in plant material, but not in tea. The study elucidates THC and CBD doses in different teas, which may assist the clinician's choice of cannabis product. Moreover, it underscores the need for caution as administration as tea can result in exposure to different doses, even when the same cannabis product is used.
(© 2024 The Author(s). Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).)
Databáze: MEDLINE
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