Relationship between serum uric acid, nocturnal hypertension and risk for preeclampsia in high-risk pregnancies.

Autor: Espeche WG; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina.; Facultad de Ciencias Médicas, UNLP, La Plata, Argentina., Salazar MR; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina. mrsalazar@med.unlp.edu.ar.; Facultad de Ciencias Médicas, UNLP, La Plata, Argentina. mrsalazar@med.unlp.edu.ar., Minetto J; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina.; Facultad de Ciencias Médicas, UNLP, La Plata, Argentina., Cerri G; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina., Carrera Ramos P; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina., Soria A; Servicio de Obstetricia, Hospital Gral. San Martín, La Plata, Argentina., Santillan C; Servicio de Obstetricia, Hospital Gral. San Martín, La Plata, Argentina., Grassi F; Servicio de Obstetricia, Hospital Gral. San Martín, La Plata, Argentina., Torres S; Servicio de Obstetricia, Hospital Gral. San Martín, La Plata, Argentina., Carbajal HA; Unidad de Enfermedades Cardiometabólicas, Servicio de Clínica Médica, Hospital Gral. San Martín, La Plata, Argentina.
Jazyk: angličtina
Zdroj: Journal of human hypertension [J Hum Hypertens] 2024 Sep; Vol. 38 (9), pp. 642-648. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1038/s41371-024-00939-w
Abstrakt: To analyze the possible association between serum uric acid (SUA) and nocturnal hypertension and to evaluate the ability of these variables (alone or in combination) to predict preeclampsia (PE) we conducted a historical cohort study in 532 high-risk pregnancies. Women were divided according to SUA values and nocturnal blood pressure (BP) into four groups: 1- normal SUA and nocturnal normotension; 2- high SUA and nocturnal normotension; 3- normal SUA and nocturnal hypertension and 4- high SUA and nocturnal hypertension. High SUA was defined by the top quartile values and nocturnal hypertension as BP ≥ 120/70 mmHg, using ambulatory blood pressure monitoring (ABPM), during nocturnal rest. Risks for PE were compared using logistic regression. SUA had a weak but significant correlation with daytime systolic ABPM (r = 0.11, p = 0.014), daytime diastolic ABPM (r = 0.13, p = 0.004), nighttime systolic ABPM (r = 0.16, p < 0.001) and nighttime diastolic ABPM (r = 0.18, p < 0.001). Also, all ABPM values were higher in women with high SUA. The absolute risk of PE increased through groups: 6.5%, 13.1%, 31.2%, and 47.9% for groups 1, 2, 3, and 4, respectively, p < 0.001. Compared with Group 1, Group 3 (OR 6.29 95%CI 3.41-11.60), but not Group 2 (OR 2.15 95%CI 0.88-5.24), had statistically significant higher risk for PE. Group 4 (women with both, high SUA and nocturnal hypertension) had the highest risk (OR 13.11 95%CI 6.69-25.70). Risks remained statistically significant after the adjustment for relevant variables. In conclusion, the combination of SUA > 4 mg/dL and nocturnal BP > 120/70 mmHg implies a very high risk to developed PE.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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