IRF8 and MAFB drive distinct transcriptional machineries in different resident macrophages of the central nervous system.

Autor: Yamasaki A; Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University, Fukuoka, Japan., Imanishi I; Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Tanaka K; Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Ohkawa Y; Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Tsuda M; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Science, Kyushu University, Fukuoka, Japan., Masuda T; Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. takahiro.masuda@bioreg.kyushu-u.ac.jp.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Jul 24; Vol. 7 (1), pp. 896. Date of Electronic Publication: 2024 Jul 24.
DOI: 10.1038/s42003-024-06607-6
Abstrakt: The central nervous system (CNS) includes anatomically distinct macrophage populations including parenchyma microglia and CNS-associated macrophages (CAMs) localized at the interfaces like meninges and perivascular space, which play specialized roles for the maintenance of the CNS homeostasis with the help of precisely controlled gene expressions. However, the transcriptional machinery that determines their cell-type specific states of microglia and CAMs remains poorly understood. Here we show, by myeloid cell-specific deletion of transcription factors, IRF8 and MAFB, that both adult microglia and CAMs utilize IRF8 to maintain their core gene signatures, although the genes altered by IRF8 deletion are different in the two macrophage populations. By contrast, MAFB deficiency robustly affected the gene expression profile of adult microglia, whereas CAMs are almost independent of MAFB. Our data suggest that distinct transcriptional machineries regulate different macrophages in the CNS.
(© 2024. The Author(s).)
Databáze: MEDLINE
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