Evolution of ion channels in cetaceans: a natural experiment in the tree of life.

Autor: Uribe C; Department of Bioinformatics, Program in Sciences Mention Modeling of Chemical and Biological Systems, School of Bioinformatics Engineering, Center for Bioinformatics, Simulation and Modeling, CBSM, Faculty of Engineering, University of Talca, Campus Talca, Talca, Chile., Nery MF; Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas-UNICAMP, Cidade Universitária, Campinas, Brazil., Zavala K; Facultad de Medicina y Ciencia, Universidad San Sebastián, Valdivia, Chile., Mardones GA; Facultad de Medicina y Ciencia, Universidad San Sebastián, Valdivia, Chile.; Integrative Biology Group, Valdivia, Chile., Riadi G; Department of Bioinformatics, Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, CBSM, University of Talca, Talca, Chile. griadi@utalca.cl.; Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Valdivia, Chile. griadi@utalca.cl., Opazo JC; Facultad de Medicina y Ciencia, Universidad San Sebastián, Valdivia, Chile. juan.opazo@uss.cl.; Integrative Biology Group, Valdivia, Chile. juan.opazo@uss.cl.; Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Valdivia, Chile. juan.opazo@uss.cl.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 23; Vol. 14 (1), pp. 17024. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1038/s41598-024-66082-1
Abstrakt: Cetaceans represent a natural experiment within the tree of life in which a lineage changed from terrestrial to aquatic habitats. This shift involved phenotypic modifications, representing an opportunity to explore the genetic bases of phenotypic diversity. Among the different molecular systems that maintain cellular homeostasis, ion channels are crucial for the proper physiological functioning of all living species. This study aims to explore the evolution of ion channels during the evolutionary history of cetaceans. To do so, we created a bioinformatic pipeline to annotate the repertoire of ion channels in the genome of the species included in our sampling. Our main results show that cetaceans have, on average, fewer protein-coding genes and a higher percentage of annotated ion channels than non-cetacean mammals. Signals of positive selection were detected in ion channels related to the heart, locomotion, visual and neurological phenotypes. Interestingly, we predict that the NaV1.5 ion channel of most toothed whales (odontocetes) is sensitive to tetrodotoxin, similar to NaV1.7, given the presence of tyrosine instead of cysteine, in a specific position of the ion channel. Finally, the gene turnover rate of the cetacean crown group is more than three times faster than that of non-cetacean mammals.
(© 2024. The Author(s).)
Databáze: MEDLINE
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