Complex trait susceptibilities and population diversity in a sample of 4,145 Russians.

Autor: Usoltsev D; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia.; Broad Institute, Cambridge, MA, USA.; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Kolosov N; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia.; Broad Institute, Cambridge, MA, USA.; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Rotar O; Almazov National Medical Research Centre, St Petersburg, Russia., Loboda A; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia.; Broad Institute, Cambridge, MA, USA., Boyarinova M; Almazov National Medical Research Centre, St Petersburg, Russia., Moguchaya E; Almazov National Medical Research Centre, St Petersburg, Russia., Kolesova E; Almazov National Medical Research Centre, St Petersburg, Russia., Erina A; Almazov National Medical Research Centre, St Petersburg, Russia., Tolkunova K; Almazov National Medical Research Centre, St Petersburg, Russia., Rezapova V; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia.; Broad Institute, Cambridge, MA, USA., Molotkov I; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Melnik O; Almazov National Medical Research Centre, St Petersburg, Russia., Freylikhman O; Almazov National Medical Research Centre, St Petersburg, Russia., Paskar N; Almazov National Medical Research Centre, St Petersburg, Russia., Alieva A; Almazov National Medical Research Centre, St Petersburg, Russia., Baranova E; Almazov National Medical Research Centre, St Petersburg, Russia., Bazhenova E; Almazov National Medical Research Centre, St Petersburg, Russia., Beliaeva O; Almazov National Medical Research Centre, St Petersburg, Russia., Vasilyeva E; Almazov National Medical Research Centre, St Petersburg, Russia., Kibkalo S; Almazov National Medical Research Centre, St Petersburg, Russia., Skitchenko R; Almazov National Medical Research Centre, St Petersburg, Russia., Babenko A; Almazov National Medical Research Centre, St Petersburg, Russia., Sergushichev A; ITMO University, St Petersburg, Russia., Dushina A; Orenburg State Medical University, Orenburg, Russia., Lopina E; Orenburg State Medical University, Orenburg, Russia., Basyrova I; Orenburg State Medical University, Orenburg, Russia., Libis R; Orenburg State Medical University, Orenburg, Russia., Duplyakov D; Samara State Medical University, Samara, Russia.; Samara Regional Cardiology Dispensary, Samara, Russia., Cherepanova N; Samara Regional Cardiology Dispensary, Samara, Russia., Donner K; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland., Laiho P; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Kostareva A; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia., Konradi A; Almazov National Medical Research Centre, St Petersburg, Russia.; ITMO University, St Petersburg, Russia., Shlyakhto E; Almazov National Medical Research Centre, St Petersburg, Russia., Palotie A; Broad Institute, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Daly MJ; Broad Institute, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Artomov M; Almazov National Medical Research Centre, St Petersburg, Russia. mykyta.artomov@nationwidechildrens.org.; ITMO University, St Petersburg, Russia. mykyta.artomov@nationwidechildrens.org.; Broad Institute, Cambridge, MA, USA. mykyta.artomov@nationwidechildrens.org.; The Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA. mykyta.artomov@nationwidechildrens.org.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. mykyta.artomov@nationwidechildrens.org.; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland. mykyta.artomov@nationwidechildrens.org.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. mykyta.artomov@nationwidechildrens.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 23; Vol. 15 (1), pp. 6212. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1038/s41467-024-50304-1
Abstrakt: The population of Russia consists of more than 150 local ethnicities. The ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the population uniquely positioned to investigate the shared properties of inherited disease risks between European and Asian ancestries. We present the analysis of genetic and phenotypic data from a cohort of 4,145 individuals collected in three metro areas in western Russia. We show the presence of multiple admixed genetic ancestry clusters spanning from primarily European to Asian and high identity-by-descent sharing with the Finnish population. As a result, there was notable enrichment of Finnish-specific variants in Russia. We illustrate the utility of Russian-descent cohorts for discovery of novel population-specific genetic associations, as well as replication of previously identified associations that were thought to be population-specific in other cohorts. Finally, we provide access to a database of allele frequencies and GWAS results for 464 phenotypes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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