Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy.

Autor:	Crespo Pimentel B; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria bcpimentel93@gmail.com b.wandschneider@ucl.ac.uk.; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK., Kuchukhidze G; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria., Xiao F; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK., Caciagli L; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK.; Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern, Switzerland., Höfler J; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria., Rainer L; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.; Department of Child and Adolescence Psychiatry, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria., Kronbichler M; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria.; Department of Psychology, University of Salzburg, Salzburg, Austria., Vollmar C; Department of Neurology, Epilepsy Center, University Hospital of the Ludwig-Maximilians-University of Munich, Munich, Germany., Duncan JS; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK., Trinka E; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria.; Department of Public Health, Health Services Research and Health Technology Assessment, University of Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.; Karl Landsteiner Institute for Neurorehabilitation and Space Neurology, Salzburg, Austria., Koepp M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK., Wandschneider B; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK bcpimentel93@gmail.com b.wandschneider@ucl.ac.uk.; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK.
Jazyk:	angličtina
Zdroj:	Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2024 Dec 16; Vol. 96 (1), pp. 11-14. Date of Electronic Publication: 2024 Dec 16.
DOI:	10.1136/jnnp-2024-333703
Abstrakt:	Background: Juvenile myoclonic epilepsy (JME) is associated with cortical thinning of the motor areas. The relative contribution of antiseizure medication to cortical thickness is unknown. We aimed to investigate how valproate influences the cortical morphology of JME. Methods: In this cross-sectional study, individuals with JME with and without valproate, with temporal lobe epilepsy (TLE) with valproate and controls were selected through propensity score matching. Participants underwent T1-weighted brain imaging and vertex-wise calculation of cortical thickness. Results: We matched 36 individuals with JME on valproate with 36 individuals with JME without valproate, 36 controls and 19 individuals with TLE on valproate. JME on valproate showed thinning of the precentral gyri (left and right, p<0.001) compared with controls and thinning of the left precentral gyrus when compared with JME not on valproate (p<0.01) or to TLE on valproate (p<0.001). Valproate dose correlated negatively with the thickness of the precentral gyri, postcentral gyri and superior frontal gyrus in JME (left and right p<0.0001), but not in TLE. Conclusions: Valproate was associated with JME-specific and dose-dependent thinning of the cortical motor regions. This suggests that valproate is a key modulator of cortical morphology in JME, an effect that may underlie its high efficacy in this syndrome. Competing Interests: Competing interests: BCP was supported by a scholarship from the Austrian Society of Epileptology, which was not directly related to this project. ET reports personal fees from EVER Pharma, Marinus, Argenx, Arvelle/Angelini, Medtronic, Bial-Portela and Cª, NewBridge, GL Pharma, GlaxoSmithKline, Hikma, Boehringer Ingelheim, LivaNova, Eisai, UCB, Biogen, Genzyme Sanofi, GW Pharmaceuticals/Jazz and Actavis outside the submitted work; his institution has received grants from Biogen, UCB Pharma, Eisai, Red Bull, Merck, Bayer, the European Union, FWF Osterreichischer Fond zur Wissenschaftsforderung, Bundesministerium für Wissenschaft und Forschung and Jubilaumsfond der Österreichischen Nationalbank outside the submitted work. MK has received honoraria from Biocodex, Bial, GE, GSK, LivaNova, Eisai, UCB, Jazz Pharmaceuticals, and research funding from MRC, the Wellcome Trust, ER-UK, the Henry Smith Foundation and the Epilepsy Society. BW received salary support from the German Research Foundation (WA3135/1-1). The remaining authors have no conflicts of interest. (© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.)
Databáze:	MEDLINE
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