Influence of bite force and implant elastic modulus on mandibular reconstruction with particulate-cancellous bone marrow grafts healing: An in silico investigation.

Autor: Sulaiman MY; Mechanics of Solid and Lightweight Structures Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia., Wicaksono S; Mechanics of Solid and Lightweight Structures Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia. Electronic address: satrio_wicaksono@itb.ac.id., Dirgantara T; Mechanics of Solid and Lightweight Structures Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia., Mahyuddin AI; Dynamics and Control Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia., Sadputranto SA; Oral and Maxillofacial Medical Staff Group, Hasan Sadikin General Hospital, Jalan Pasteur 38, Bandung, 40161, West Java, Indonesia; Oral and Maxillofacial Department, Faculty of Dentistry, Universitas Padjajaran, Jalan Sekeloa Selatan 1, Bandung, 40132, West Java, Indonesia., Oli'i EM; Oral and Maxillofacial Medical Staff Group, Hasan Sadikin General Hospital, Jalan Pasteur 38, Bandung, 40161, West Java, Indonesia; Oral and Maxillofacial Department, Faculty of Dentistry, Universitas Padjajaran, Jalan Sekeloa Selatan 1, Bandung, 40132, West Java, Indonesia; Mechanical Engineering Graduate Program, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, West Java, Indonesia.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Sep; Vol. 157, pp. 106654. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.jmbbm.2024.106654
Abstrakt: This study aims to investigate tissue differentiation during mandibular reconstruction with particulate cancellous bone marrow (PCBM) graft healing using biphasic mechanoregulation theory under four bite force magnitudes and four implant elastic moduli to examine its implications on healing rate, implant stress distribution, new bone elastic modulus, mandible equivalent stiffness, and load-sharing progression. The finite element model of a half Canis lupus mandible, symmetrical about the midsagittal plane, with two marginal defects filled by PCBM graft and stabilized by porous implants, was simulated for 12 weeks. Eight different scenarios, which consist of four bite force magnitudes and four implant elastic moduli, were tested. It was found that the tissue differentiation pattern corroborates the experimental findings, where the new bone propagates from the superior side and the buccal and lingual sides in contact with the native bone, starting from the outer regions and progressing inward. Faster healing and quicker development of bone graft elastic modulus and mandible equivalent stiffness were observed in the variants with lower bite force magnitude and or larger implant elastic modulus. A load-sharing condition was found as the healing progressed, with M3 (Ti6Al4V) being better than M4 (stainless steel), indicating the higher stress shielding potentials of M4 in the long term. This study has implications for a better understanding of mandibular reconstruction mechanobiology and demonstrated a novel in silico framework that can be used for post-operative planning, failure prevention, and implant design in a better way.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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