Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value.

Autor: Gao L; Department of Intensive Care Medicine, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China., Liu Q; Department of Respiratory and Critical Care Medicine, Ganzhou Fifth People's Hospital, Ganzhou City, Jiangxi Province, China., Kuang Z; Department of Intensive Care Medicine, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China., Yuan S; Department of Intensive Care Medicine, Xinfeng County People's Hospital, Ganzhou City, Jiangxi Province, China.
Jazyk: angličtina
Zdroj: The Libyan journal of medicine [Libyan J Med] 2024 Dec 31; Vol. 19 (1), pp. 2383025. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1080/19932820.2024.2383025
Abstrakt: To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of the patient's condition, they were separated into sepsis group ( n  = 76), severe sepsis group ( n  = 59), and sepsis shock group ( n  = 45). Based on the survival within 28 days of admission, they were grouped into survivors group ( n  = 128) and nonsurvivors group ( n  = 52). The serum Midkine level and APACHE II score in the sepsis shock group were higher than those in the severe sepsis group and sepsis group, while the Omentin-1 level was lower than that in the severe sepsis group and sepsis group ( p  < 0.05). The serum Midkine level and APACHE II score in the severe sepsis group were higher than those in the sepsis group, while the Omentin-1 level was lower than that in the sepsis group ( p  < 0.05). The Midkine and APACHE II score in the nonsurvivors group was higher than those in the survivors group, while the Omentin-1 score was lower than that in the survivors group ( p  < 0.05). Midkine and APACHE II score were independent risk factors for the prognosis of sepsis patients, while Omentin-1 was a protective factor for the prognosis of sepsis patients ( p  < 0.05). The AUC of the combined prediction of serum Midkine and Ommentin-1 for the prognosis of sepsis patients was 0.880, with a sensitivity of 90.38% and a specificity of 72.66%. The combined prediction of serum Midkine and Ommentin-1 was better than that of individual prediction of Midkine and Ommentin-1. Serum Midkine is highly expressed and Omentin-1 is lowly expressed in sepsis patients, and the combination of the two has a high predictive power for the prognosis of sepsis patients.
Databáze: MEDLINE
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