| Autor: |
Gao L; Department of Intensive Care Medicine, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China., Liu Q; Department of Respiratory and Critical Care Medicine, Ganzhou Fifth People's Hospital, Ganzhou City, Jiangxi Province, China., Kuang Z; Department of Intensive Care Medicine, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China., Yuan S; Department of Intensive Care Medicine, Xinfeng County People's Hospital, Ganzhou City, Jiangxi Province, China. |
| Jazyk: |
angličtina |
| Zdroj: |
The Libyan journal of medicine [Libyan J Med] 2024 Dec 31; Vol. 19 (1), pp. 2383025. Date of Electronic Publication: 2024 Jul 23. |
| DOI: |
10.1080/19932820.2024.2383025 |
| Abstrakt: |
To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of the patient's condition, they were separated into sepsis group ( n = 76), severe sepsis group ( n = 59), and sepsis shock group ( n = 45). Based on the survival within 28 days of admission, they were grouped into survivors group ( n = 128) and nonsurvivors group ( n = 52). The serum Midkine level and APACHE II score in the sepsis shock group were higher than those in the severe sepsis group and sepsis group, while the Omentin-1 level was lower than that in the severe sepsis group and sepsis group ( p < 0.05). The serum Midkine level and APACHE II score in the severe sepsis group were higher than those in the sepsis group, while the Omentin-1 level was lower than that in the sepsis group ( p < 0.05). The Midkine and APACHE II score in the nonsurvivors group was higher than those in the survivors group, while the Omentin-1 score was lower than that in the survivors group ( p < 0.05). Midkine and APACHE II score were independent risk factors for the prognosis of sepsis patients, while Omentin-1 was a protective factor for the prognosis of sepsis patients ( p < 0.05). The AUC of the combined prediction of serum Midkine and Ommentin-1 for the prognosis of sepsis patients was 0.880, with a sensitivity of 90.38% and a specificity of 72.66%. The combined prediction of serum Midkine and Ommentin-1 was better than that of individual prediction of Midkine and Ommentin-1. Serum Midkine is highly expressed and Omentin-1 is lowly expressed in sepsis patients, and the combination of the two has a high predictive power for the prognosis of sepsis patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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