A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery.

Autor:	Hirsch IB; University of Washington, Seattle, WA., Beck RW; JAEB Center for Health Research, Tampa, FL., Marak MC; JAEB Center for Health Research, Tampa, FL., Calhoun P; JAEB Center for Health Research, Tampa, FL., Mottalib A; Joslin Diabetes Center, Boston, MA., Salhin A; Diabetes & Glandular Disease Clinic, San Antonio, TX., Manessis A; NYC Research, Inc., Long Island, NY., Coviello AD; University of North Carolina, Chapel Hill, NC., Bhargava A; Iowa Diabetes and Endocrinology Research Center, West Des Moines, IA., Thorsell A; Sansum Diabetes Research Institute, Santa Barbara, CA., Atakov Castillo A; Boston Medical Center, Boston, MA., Bode BW; Atlanta Diabetes Associates, Atlanta, GA., Levister C; Icahn School of Medicine at Mount Sinai, New York, NY., Levy CJ; Icahn School of Medicine at Mount Sinai, New York, NY., Donahue C; University of North Carolina, Chapel Hill, NC., Cordero C; Loma Linda University, Loma Linda, CA., Beatson C; Barbara Davis Center for Diabetes, Denver, CO., Langel CR; Iowa Diabetes and Endocrinology Research Center, West Des Moines, IA., Jacobson C; Loma Linda University, Loma Linda, CA., Kurek C; Mayo Clinic, Rochester, MN., Cruse D; Mountain State Diabetes, Parkersburg, WV., Pickering D; Mountain State Diabetes, Parkersburg, WV., Tamarez D; Icahn School of Medicine at Mount Sinai, New York, NY., Steenkamp DW; Boston Medical Center, Boston, MA., Desjardins D; Mayo Clinic, Rochester, MN., Aleppo G; Northwestern University, Chicago, IL., O'Malley G; Icahn School of Medicine at Mount Sinai, New York, NY., Akturk HK; Barbara Davis Center for Diabetes, Denver, CO., Diner J; University of North Carolina, Chapel Hill, NC., Baran JD; University of Washington, Seattle, WA., Buse JB; University of North Carolina, Chapel Hill, NC., Ruedy K; JAEB Center for Health Research, Tampa, FL., Codorniz K; Loma Linda University, Loma Linda, CA., Klein KR; University of North Carolina, Chapel Hill, NC., Castorino K; Sansum Diabetes Research Institute, Santa Barbara, CA., Jordan LF; University of Texas Southwestern, Dallas, TX., Kipnes M; Diabetes & Glandular Disease Clinic, San Antonio, TX., Church MM; Sansum Diabetes Research Institute, Santa Barbara, CA., Hamdy O; Joslin Diabetes Center, Boston, MA., Raskin P; University of Texas Southwestern, Dallas, TX., Nguyen QT; Las Vegas Endocrinology, Henderson, NV., Weinstock RS; SUNY Upstate Medical University, Syracuse, NY., Lee S; Loma Linda University, Loma Linda, CA., Rizvi S; Mayo Clinic, Rochester, MN., Bzdick S; Boston Medical Center, Boston, MA., Ghorbani Rodriguez T; University of North Carolina, Chapel Hill, NC., Salah T; Joslin Diabetes Center, Boston, MA., Blevins T; Texas Diabetes & Endocrinology, Austin, TX., Kudva YC; Mayo Clinic, Rochester, MN., Haider Z; Barbara Davis Center for Diabetes, Denver, CO.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2024 Sep 01; Vol. 47 (9), pp. 1682-1687.
DOI:	10.2337/dc24-0838
Abstrakt:	Objective: To compare postprandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analog (RAA) insulin. Research Design and Methods: A meal challenge was completed by 122 adults with type 1 diabetes who were using multiple daily injections (MDI), a nonautomated pump, or automated insulin delivery (AID) and who were randomized to bolus with their usual RAA insulin (n = 61) or TI (n = 61). Results: The primary outcome, the treatment group difference in area under the curve for glucose >180 mg/dL over 2 h, was less with TI versus RAA (adjusted difference -12 mg/dL, 95% CI -22 to -2, P = 0.02). With TI, the glucose excursion was smaller (P = 0.01), peak glucose lower (P = 0.01), and time to peak glucose shorter (P = 0.006). Blood glucose <70 mg/dL occurred in one participant in each group. Conclusions: Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users. (© 2024 by the American Diabetes Association.)
Databáze:	MEDLINE
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