Exploring the relationship between caffeine metabolism-related CYP1A2 rs762551 polymorphism and team sport athlete status and training adaptations.

Autor: Kazan HH; Department of Medical Biology, Gulhane Faculty of Medicine, University of Health Sciences, Ankara, 06010, Türkiye., Bulgay C; Sports Science Faculty, Bingol University, Bingol, 12000, Türkiye., Zorba E; Faculty Faculty of Sport Sciences, Mugla Sıtkı Kocman University, Muğla, 48000, Türkiye., Dalip M; Faculty of Physical Culture and Health, University in Tetovo, Tetova, 1200, Republic of North Macedonia., Ceylan HI; Physical Education and Sports Teaching Department, Kazim Karabekir Faculty of Education, Ataturk University, Erzurum, 25240, Türkiye., Semenova EA; Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.; Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, Kazan, 420138, Russia., Larin AK; Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Kulemin NA; Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Generozov EV; Department of Molecular Biology and Genetics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Ahmetov II; Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, Kazan, 420012, Russia. i.akhmetov@ljmu.ac.uk.; Department of Physical Education, Plekhanov Russian University of Economics, Moscow, 115093, Russia. i.akhmetov@ljmu.ac.uk.; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 5AF, UK. i.akhmetov@ljmu.ac.uk., Cerit M; Sports Science Faculty, Lokman Hekim University, Ankara, 06510, Türkiye.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Jul 23; Vol. 51 (1), pp. 841. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1007/s11033-024-09800-2
Abstrakt: Background: This study aimed to achieve a dual objective: to compare the frequencies of CYP1A2 rs762551 genotypes between team sport athletes and a control group, and to determine the association between the rs762551 polymorphism and changes in physical performance after a six-week training program among elite basketball players.
Methods: The study encompassed an analysis of 504 individuals, comprising 320 athletes and 184 controls. For the Turkish cohort, DNA was isolated using the buccal swab method, and genotyping was conducted using the KASP technique. Performance assessments included the Yo-Yo IR2 and 30 m sprint tests. For Russian participants, DNA samples were extracted from peripheral blood, a commercial kit was used for DNA extraction, and genotyping of the rs762551 polymorphism was conducted using DNA microarray.
Result: Notably, a statistically significant linear decline in the prevalence of the CC genotype was observed with ascending levels of athletic achievement within team sports (sub-elite: 18.0%, elite: 8.2%, highly elite: 0%; p = 0.001). Additionally, the CA genotype was the most prevalent genotype in the highly elite group compared to controls (80.0% vs. 45.1%, p = 0.048). Furthermore, statistically significant improvements in Yo-Yo IR2 performance were noted exclusively among basketball players harboring the CA genotype (p = 0.048).
Conclusions: The study's findings indicate that the rs762551 CC genotype is a disadvantage in elite team sports, whereas the CA genotype provides an advantage in basketball performance.
(© 2024. The Author(s).)
Databáze: MEDLINE
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