Potential therapeutic properties of broccoli extract and soy isoflavones on improvement endometriosis and involved oxidative parameters.

Autor:	Sabetian S; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Archin Dialameh P; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Tanideh N; Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Gharesifard B; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Ahmadi M; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Valibeigi M; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Kumar PV; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Siahbani S; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Namavar Jahromi B; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Hazrat-e-Zeynab Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk:	angličtina
Zdroj:	Hormone molecular biology and clinical investigation [Horm Mol Biol Clin Investig] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23.
DOI:	10.1515/hmbci-2023-0071
Abstrakt:	Objectives: In Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity that is associated with chronic pelvic pain and subfertility. The purpose of the study was to investigate the effect of broccoli extract (BE) alone and in combination with soy isoflavones (SI) on endometrial implants in female rat. Methods: In this study, endometriosis was induced surgically in 40 mature female rats. The rats were divided into 5 groups that were treated by oral gavage for 6 weeks with 0.5 mL of saline 0.9 %/day (control group), BE (3,000 mg/kg/day), SI (50 mg/kg/day), BE/soy isoflavones (BE 3000 mg/kg/day + soy isoflavones 50 mg/kg/day) and diphereline as a standard medication (3 mg/kg) intramuscularly. At the end of treatments, the volume and histopathology of the endometrial implants were compared among the 5 groups. The serum levels of oxidative parameters including superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) were also compared between the groups. The volume of the implants significantly decreased in diphereline group (p=0.002). Results: The histopathological grade of endometrial implants in BE/SI and diphereline group were significantly decreased compared to the control group (p=0.001). The serum levels of SOD in BE group were enhanced significantly in comparison to the control group (p=0.034). Conclusions: BE in combination with SI decreased the growth and histopathologic grades of transplanted endometrial implants. These herbal compounds may have the potential therapeutic effect to be used as an alternative medication for the treatment of endometriosis. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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