Would you? Effects of oxytocin on moral choices in forensic psychopathic patients.

Autor:	Rijnders RJP; Netherlands Institute for Forensic Psychiatry and Psychology, Forensic Observation Clinic 'Pieter Baan Centrum', Carl Barksweg 3, 1336, ZL, Almere, the Netherlands.; Utrecht University, Faculty of Social Sciences, Department of Psychology, Heidelberglaan 8, 3584, CS, Utrecht, the Netherlands., van den Hoogen S; Netherlands Institute for Forensic Psychiatry and Psychology, Forensic Observation Clinic 'Pieter Baan Centrum', Carl Barksweg 3, 1336, ZL, Almere, the Netherlands., van Honk J; Utrecht University, Faculty of Social and Behavioural Sciences, Department of Psychology, Heidelberglaan 8, 3584, CS, Utrecht, the Netherlands.; University of Cape Town, Department of Psychiatry and Mental Health J-Block, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa.; University of Cape Town, Institute of Infectious Diseases and Molecular Medicine, Anzio Rd, Observatory, 7925, Cape Town, South Africa., Terburg D; Utrecht University, Faculty of Social Sciences, Department of Psychology, Heidelberglaan 8, 3584, CS, Utrecht, the Netherlands.; University of Cape Town, Institute of Infectious Diseases and Molecular Medicine, Anzio Rd, Observatory, 7925, Cape Town, South Africa., Kempes MM; Netherlands Institute for Forensic Psychiatry and Psychology, Department of Science and Education, Herman Gorterstraat 5, 3511, EW, Utrecht, the Netherlands.; Leiden University, Faculty of Social and Behavioural Sciences, Institute of Education and Child Studies, Wassenaarseweg 52, 2333, AK, Leiden, the Netherlands.
Jazyk:	angličtina
Zdroj:	Comprehensive psychoneuroendocrinology [Compr Psychoneuroendocrinol] 2024 Jun 26; Vol. 19, pp. 100245. Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024).
DOI:	10.1016/j.cpnec.2024.100245
Abstrakt:	Psychopaths are suggested to be more likely to favor utilitarian outcomes over non-utilitarian (i.e., deontological) choices. Here we re-test this hypothesis and investigate whether oxytocin, a hormone associated with empathy, can counter this utilitarian effect. Forensic psychopathic patients and non-psychopathic controls participated in a sacrificial moral decision-making paradigm. Psychopathic patients performed the task in a double-blind cross-over placebo-controlled oxytocin administration paradigm. We found no evidence for psychopathic patients to act more utilitarian (or sacrificial) or any effect of oxytocin administration. Psychopathic traits within the control group, particularly traits associated with lack of empathy and failure to consider consequences, were however associated with more utilitarian choices, but only when these actions were low in emotion. In contrast, psychopathy severity in psychopathic patients, particularly impulsivity-related traits, predicts deontological choices, but only in highly emotional actions. Thus, although psychopathic traits do predict utilitarianism when emotional investment is low, this is not the case in full-blown psychopathy. Instead, there is a link between impulsivity and deontological choices in psychopathic patients, but only when emotional investment is high, and self-interest is not at stake. These preliminary results are discussed to whether utilitarian outcomes align with the personal goals of psychopathic individuals. Competing Interests: We report no biomedical financial interests or potential conflicts of interest. JvH received a grant from the Dutch Research Council's (10.13039/501100003246NWO) National Initiative Brain & Cognition - social innovation in healthcare, education and safety. (© 2024 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu