Comparing Left Ventricular Structure and Functions in End-Stage Renal Disease Using Conventional Echocardiography and 2D Speckle Tracking Echocardiography.

Autor:	Habib SA; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Hasan AA; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Abd Elaziz OH; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Ibrahim AH; Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Ali TA; Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Kotb FM; Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Khalaf H; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Omar MA; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Damietta, EGY., Said IF; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Shokr AM; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Elkhouly AA; Department of Cardiology, Islamic Cardiac Center, Al-Azhar University, Cairo, EGY., Faheem AA; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, EGY., Abbas AM; Department of Urology and Nephrology, National Institute of Nephrology, Cairo, EGY., Dabash TA; Department of Cardiology, Faculty of Medicine, Al-Azhar University, Damietta, EGY., Hefzy MM; Department of Nephrology, Medcare Hospital, Sharjah, ARE., Aboomar AA; Department of Internal Medicine, Nephrology Unit, Faculty Medicine, Tanta University, Tanta, EGY.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 22; Vol. 16 (6), pp. e62926. Date of Electronic Publication: 2024 Jun 22 (Print Publication: 2024).
DOI:	10.7759/cureus.62926
Abstrakt:	Background: Patients on hemodialysis (HD) are prone to various cardiovascular complications. Two-dimensional speckle tracking echocardiography (2D STE) is an innovative technique for early myocardial dysfunction detection, even with normal ejection fraction (EF). Objective: We aim to detect left ventricle (LV) dysfunction in regular hemodialysis patients using 2D STE compared to traditional echocardiography. Methods: The study comprised 30 patients with end-stage renal disease (ESRD), subdivided according to left ventricular mass index (LVMI) into group 1 with left ventricular hypertrophy (LVH) (n=19) and group 2 without LVH (n=11). Another 30 healthy control subjects were recruited as group 3. The EF, average systolic velocity (Sa), and 2D LV strain were taken as measures of LV systolic function. The indicators for diastolic function included the E/A ratio and E velocity/peak early diastolic velocity. Results: Regarding the parameters of LV systolic and diastolic functions assessed by traditional echocardiography, we found no significant difference between groups 1 and 2. However, using 2D STE, we observed significant differences in the average Sa velocity (p=0.025), average LV strain (p=0.03), 2D global longitudinal strain (GLS) (p=0.03), E/Ea (p=0.003), and LV myocardial performance index (MPI) (p=0.006). Also, a significant positive correlation was found between LVMI and left ventricular end-diastolic diameter (LVEDD) (p<0.01, r=0.63), EF measured by 2D (p=0.034, r=0.39), mitral E/A ratio (p=0.03, r=0.49), and mitral E/Ea (p<0.01, r=0.72). There was a significantly strong negative correlation between LVMI and 2D average LV strain (p=0.034, r=-0.39). Conclusion: We concluded that 2D STE is more sensitive than a conventional echo in detecting early LV systolic and diastolic dysfunction even in patients with normal EF. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. The Research Ethics Committee of Al-Azhar University Institutional Review Board (IRB) issued approval RHDIRB/2018122001. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Habib et al.)
Databáze:	MEDLINE
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