Cytotoxic clerodane diterpenoids from the roots of Casearia barteri Mast.

Autor: Tabekoueng GB; Department of Chemistry, Chemistry Laboratory, Faculty of Science, University of Douala P. O. Box 24157 Douala Cameroon., Fomo Fozing FA; Department of Chemistry, Chemistry Laboratory, Faculty of Science, University of Douala P. O. Box 24157 Douala Cameroon., Mas-Claret E; Royal Botanic Gardens Kew TW9 3AE Richmond Surrey UK., Langat MK; Royal Botanic Gardens Kew TW9 3AE Richmond Surrey UK., Frese M; Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University D-33501 Bielefeld Germany., Bissoue AN; Department of Chemistry, Chemistry Laboratory, Faculty of Science, University of Douala P. O. Box 24157 Douala Cameroon., Wansi JD; Department of Chemistry, Chemistry Laboratory, Faculty of Science, University of Douala P. O. Box 24157 Douala Cameroon., Kamdem Waffo AF; Department of Chemistry, Chemistry Laboratory, Faculty of Science, University of Douala P. O. Box 24157 Douala Cameroon., Sewald N; Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University D-33501 Bielefeld Germany., Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I P. O. Box 47 Yaoundé Cameroon.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Jul 22; Vol. 14 (32), pp. 23109-23117. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024).
DOI: 10.1039/d4ra04393f
Abstrakt: A study of diterpenoids as active ingredients against cancer from the active roots extract of Casearia barteri Mast. (IC 50 = 1.57 μg mL -1 ) led to the isolation of six new clerodane diterpenoids, named as barterins A-F (1-6) alongside seven known compounds, caseamembrin A, caseamembrin E, casearlucin A, graveospene G, N-trans -feruloyltyramine, N-cis -feruloytyramine and sitosterol-3- O -β- D -(6- O -palmitoyl)-glucopyranoside. Their structures were elucidated based on NMR spectroscopic data and mass spectrometry. The absolute configurations of 1-6 were established by the time-dependent density functional theory (TDDFT), electronic circular dichroism (ECD) calculations and experimental data analysis. The cytotoxic effects of compounds 1-6 were evaluated against a human cervix carcinoma cell line KB -3-1. Barterins A-D (1-4) showed cytotoxic effects against the KB -3-1 cell line with IC 50 values ranging from 1.34-4.73 μM.
Competing Interests: The authors declare no conflict of interest that could have appeared to influence the work reported in this paper.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
Externí odkaz: