Understanding interobserver variability of pathologists to improve oral epithelial dysplasia grading.

Autor: Ng GTE; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Phang SC; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Yu KS; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Tiwari L; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia., Khurram SA; Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK., Sloan P; School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; AMLo Biosciences, Newcastle upon Tyne, UK., Kujan O; UWA Dental School, The University of Western Australia, Nedlands, Western Australia, Australia.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1111/odi.15078
Abstrakt: Objective: This study aimed to understand reasons for interobserver variability in the grading of oral epithelial dysplasia (OED) through a survey of pathologists to provide insight for improvements in the reliability and reproducibility of OED diagnoses.
Methods: The study design included quantitative and qualitative methodology. A pre-validated 31-item questionnaire was distributed to general, head and neck, and oral and maxillofacial histopathology specialists worldwide.
Results: A total of 132 pathologists participated and completed the questionnaire. Over two-thirds used the three-tier grading system for OED, while about a third used both binary and three-tier systems. Regular reporters of OED preferred the three-tier system and grading architectural features. Continuing education significantly aided recognition of architectural and cytological changes. Irregular epithelial stratification and drop-shaped rete ridges had the lowest prognostic value and recognition scores, while loss of epithelial cell cohesion had the highest. Most participants used clinical information and often sought a second opinion when grading OED.
Conclusion: Our study has found that frequency of OED reporting and attendance of CME/CPD can play an important role in grading OED. Variations in the prognostic value of individual histological features and the use of clinical information may further contribute to interobserver variability.
(© 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: