Exposure to obinutuzumab does not affect outcomes of SARS-CoV-2 infection in vaccinated patients with newly diagnosed advanced-stage follicular lymphoma.

Autor: Pinto A; Ematologia Oncologica, Istituto Nazionale Tumori, Fondazione 'G. Pascale', IRCCS, Naples, Italy., Caltagirone M; Medical Affairs, Roche S.p.A., Monza, Italy., Battista M; Clinical Operations, Roche S.p.A., Monza, Italy., Gazzoli GC; International Patient Safety, Roche S.p.A., Monza, Italy., Patti C; Ospedali Riuniti Villa Sofia - Cervello, Palermo, Italy., Pennese E; Unità Operativa Complessa Ematologia Presidio Ospedaliero Pescara, Pescara, Italy., De Lorenzo S; U.O.C. 'Ematologia e TMO' AORN 'S. G. Moscati', Avellino, Italy., Pavone V; Unità Operativa Complessa di Ematologia e Trapianto di Cellule Staminali Emopoietiche, Azienda Ospedaliera Cardinale Panico, Tricase, Italy., Merli M; Hematology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Chiarenza A; U.O.C. Ematologia Con TMO, Azienda Ospedaliero Universitaria Policlinico 'G. Rodolico - San Marco', Catania, Italy., Gorgone AG; UOC Ematologia ARNAS Garibaldi, Catania, Italy., Piazza F; UOC Ematologia, Azienda Ospedaliero-Universitaria di Padova, University of Padova, Padova, Italy., Puccini B; Ematologia, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Noto A; Hematology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Arcaini L; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Division of Hematology, Fondazione IRCCS Policlinico San Matteo di Pavia, University of Pavia, Pavia, Italy., De Filippi R; Dipartimento di Medicina Clinica e Chirurgia, Scuola di Medicina, Università Federico II, Naples, Italy., Zinzani PL; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy.; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy., Ferreri AJM; Lymphoma Unit, IRCCS San Raffaele Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy., Ladetto M; Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale SCDU Ematologia, AOU SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Ferrari S; UOC Ematologia Ospedale Papa Giovanni XXIII, Bergamo, Italy., Gritti G; UOC Ematologia Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2024 Dec; Vol. 205 (6), pp. 2219-2227. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1111/bjh.19661
Abstrakt: URBAN is a multicentric, ambispective study evaluating the effectiveness and safety of obinutuzumab-based immuno-chemotherapy and maintenance in patients with untreated advanced follicular lymphoma (FL). The study began before the COVID-19 emergency declaration in Italy. It is currently ongoing for follow-up, and the enrolment timeline encompassed different stages of the pandemic, various vaccination roll-out phases and prevalence of SARS-CoV-2 variants. Outcomes of interest of the present sub-analysis included SARS-CoV-2 infection rates and COVID-19-related hospitalizations/deaths. At data cut-off, 86 (28.8%) and 213 patients (71.2%) were treated before and during/after the COVID-19 outbreak respectively; 294 (98.3%) completed the induction, 31 (10.4%) completed maintenance and 170 (56.9%) were still on maintenance. Overall, 245 patients (81.9%) received at least one SARS-CoV-2 vaccine dose: 13.5%, 31.4% and 55.1% received one, two and three doses respectively. We observed a substantial decrease in COVID-19-related mortality rates in pre- versus post-vaccination phases, along with a reduction in COVID-19-related outcomes due to the shift from alpha/delta to omicron variant predominance. No differences emerged between patients given maintenance or not, although the schedule was modified in 65% of cases. To our knowledge, URBAN represents the largest dataset of COVID-19-related outcomes in FL patients extensively exposed to obinutuzumab. ClinicalTrials.gov identifier: NCT04034056.
(© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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