Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.

Autor: Chew EY; Division of Epidemiology and Clinical Applications, National Eye Institute, NIH, Bethesda, MD, USA. echew@nei.nih.gov., Burns SA; School of Optometry, Indiana University, Bloomington, IN, USA., Abraham AG; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA., Bakhoum MF; Departments of Ophthalmology and Visual Science and Pathology, School of Medicine, Yale University, New Haven, CT, USA., Beckman JA; Division of Vascular Medicine, University of Southwestern Medical Center, Dallas, TX, USA., Chui TYP; Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA., Finger RP; Department of Ophthalmology, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany., Frangi AF; Division of Informatics, Imaging and Data Science (School of Health Sciences), Department of Computer Science (School of Engineering), University of Manchester, Manchester, UK.; Alan Turing Institute, London, UK., Gottesman RF; Stroke Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Grant MB; Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama Heersink School of Medicine, Birmingham, AL, USA., Hanssen H; Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland., Lee CS; Department of Ophthalmology, University of Washington, Seattle, WA, USA., Meyer ML; Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA., Rizzoni D; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Rudnicka AR; Population Health Research Institute, St. George's University of London, London, UK., Schuman JS; Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA., Seidelmann SB; Department of Clinical Medicine, Columbia College of Physicians and Surgeons, Greenwich, CT, USA., Tang WHW; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Adhikari BB; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Danthi N; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Hong Y; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Reid D; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Shen GL; Retinal Diseases Program, Division of Extramural Science Programs, National Eye Institute, NIH, Bethesda, MD, USA., Oh YS; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: Nature reviews. Cardiology [Nat Rev Cardiol] 2025 Jan; Vol. 22 (1), pp. 47-63. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1038/s41569-024-01060-8
Abstrakt: The accessibility of the retina with the use of non-invasive and relatively low-cost ophthalmic imaging techniques and analytics provides a unique opportunity to improve the detection, diagnosis and monitoring of systemic diseases. The National Heart, Lung, and Blood Institute conducted a workshop in October 2022 to examine this concept. On the basis of the discussions at that workshop, this Roadmap describes current knowledge gaps and new research opportunities to evaluate the relationships between the eye (in particular, retinal biomarkers) and the risk of cardiovascular diseases, including coronary artery disease, heart failure, stroke, hypertension and vascular dementia. Identified gaps include the need to simplify and standardize the capture of high-quality images of the eye by non-ophthalmic health workers and to conduct longitudinal studies using multidisciplinary networks of diverse at-risk populations with improved implementation and methods to protect participant and dataset privacy. Other gaps include improving the measurement of structural and functional retinal biomarkers, determining the relationship between microvascular and macrovascular risk factors, improving multimodal imaging 'pipelines', and integrating advanced imaging with 'omics', lifestyle factors, primary care data and radiological reports, by using artificial intelligence technology to improve the identification of individual-level risk. Future research on retinal microvascular disease and retinal biomarkers might additionally provide insights into the temporal development of microvascular disease across other systemic vascular beds.
Competing Interests: Competing interests: The views expressed in this article are those of the authors and do not necessarily represent the views of the National Eye Institute; the National Heart, Lung, and Blood Institute; the NIH; or the US Department of Health and Human Services. This work was supported by the intramural programme funds of the National Eye Institute (E.Y.C.). No industry support was used for this project. J.A.B. declares consulting for Jan One, Janssen and Novartis. J.S.S. declares having served as consultant for Alcon Laboratories, Boehringer Ingelheim, Dompe and Regeneron Pharmaceutical; having served as consultant and having received grant support from Bright Focus Foundation, National Eye Institute and Perfuse; having served as consultant and being a stockholder for AEYE Heath, Ocugenex, Ocular Therapeutix, Opticient and Tarus; having served as a consultant and having received royalties from Carl Zeiss Meditec, New York University School of Medicine, SLACKS, Tufts University School of Medicine and University of Pittsburgh Medical Center. W.H.W.T. has served as a consultant for Boston Scientific, CardiaTec Biosciences, Cardiol Therapeutics, Genomics, Intellia Therapeutics, Kiniksa Pharmaceuticals, Renovacor, Sequana Medical, WhiteSwell and Zehna Therapeutics, and has received honoraria from the American Board of Internal Medicine, Belvoir Media Group and Springer. The other authors declare no competing interests.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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