New epilepsy therapies in development.

Autor: Klein P; Mid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA. kleinp@epilepsydc.com., Kaminski RM; Angelini Pharma, Rome, Italy., Koepp M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK., Löscher W; Translational Neuropharmacology Lab., NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Loescher.Wolfgang@mh-hannover.de.; Center for Systems Neuroscience, Hannover, Germany. Loescher.Wolfgang@mh-hannover.de.
Jazyk: angličtina
Zdroj: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2024 Sep; Vol. 23 (9), pp. 682-708. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1038/s41573-024-00981-w
Abstrakt: Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and increased mortality. Although people at risk can often be identified, interventions to prevent the development of the disorder are not available. Moreover, in at least 30% of patients, epilepsy cannot be controlled by current antiseizure medications (ASMs). As a result of considerable progress in epilepsy genetics and the development of novel disease models, drug screening technologies and innovative therapeutic modalities over the past 10 years, more than 200 novel epilepsy therapies are currently in the preclinical or clinical pipeline, including many treatments that act by new mechanisms. Assisted by diagnostic and predictive biomarkers, the treatment of epilepsy is undergoing paradigm shifts from symptom-only ASMs to disease prevention, and from broad trial-and-error treatments for seizures in general to mechanism-based treatments for specific epilepsy syndromes. In this Review, we assess recent progress in ASM development and outline future directions for the development of new therapies for the treatment and prevention of epilepsy.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: