A novel pilot study to evaluate the efficacy and safety of a wireless patch system in patients with chronic nausea and vomiting.

Autor: Lacy BE; Division of Gastroenterology & Hepatology, Mayo Clinic, Jacksonville, Florida, USA., Cangemi DJ; Division of Gastroenterology & Hepatology, Mayo Clinic, Jacksonville, Florida, USA., Accurso JM; Division of Nuclear Radiology, Mayo Clinic, Jacksonville, Florida, USA., Axelrod S; G-Tech Medical, Inc., Mountain View, California, USA., Axelrod L; G-Tech Medical, Inc., Mountain View, California, USA., Navalgund A; G-Tech Medical, Inc., Mountain View, California, USA.
Jazyk: angličtina
Zdroj: Neurogastroenterology and motility [Neurogastroenterol Motil] 2024 Sep; Vol. 36 (9), pp. e14862. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1111/nmo.14862
Abstrakt: Background: Gastric sensorimotor disorders (functional dyspepsia [FD] and gastroparesis [GP]) are prevalent and burdensome. Prolonged ambulatory recording using a wireless patch may provide novel information in these patients.
Methods: Consecutive adult patients (age ≥ 18 years) referred for gastric emptying scintigraphy (GES) were eligible for study inclusion. Patients were excluded if they had prior foregut surgery; were taking opioids or other medications known to affect gastric emptying; had a HgbA1C > 10; or were recently hospitalized. Three wireless motility patches were applied to the skin prior to GES. Patients wore the patches for 6 days while recording meals, symptoms, and bowel movements using an iPhone app.
Key Results: Twenty-three consecutive adults (87% women; mean age = 43.9 years; mean BMI = 26.7 kg/m 2 ) were enrolled. A gastric histogram revealed three levels of gastric myoelectric activity: weak, moderate, and strong. Patients with delayed gastric emptying at 4 h had weak gastric myoelectrical activity. Patients with nausea and vomiting had strong intestinal activity. Those with FD had weak gastric and intestinal myoelectric activity, and a weak meal response in the stomach, intestine, and colon compared to those with nausea alone or vomiting alone.
Conclusions and Inferences: Patients with FD, and those with delayed gastric emptying, had unique gastrointestinal myoelectrical activity patterns. Reduced postprandial pan-intestinal myoelectric activity may explain the symptoms of FD in some patients. Recording gastrointestinal activity over a prolonged period in the outpatient setting has the potential to identify unique pathophysiologic patterns and meal-related activity that distinguishes patients with distinct gastric sensorimotor disease states.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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