c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis.

Autor: Zhang S; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Li N; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China.; Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China., Wu S; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Xie T; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Chen Q; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Wu J; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Zeng S; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Zhu L; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Bai S; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Zha H; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Tian W; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Wu N; Shenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, P.R. China., Zou X; Shenzhen Center for Disease Control and Prevention, Shenzhen, P.R. China., Fang S; Shenzhen Center for Disease Control and Prevention, Shenzhen, P.R. China., Luo C; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China., Shi M; The Centre for Infection and Immunity Studies, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China., Sun C; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China., Shu Y; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China.; Key Laboratory of Pathogen Infection Prevention and Control (MOE), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China., Luo H; School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China.; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China.; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2024 Jul 22; Vol. 20 (7), pp. e1012408. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024).
DOI: 10.1371/journal.ppat.1012408
Abstrakt: c-FLIP functions as a dual regulator of apoptosis and inflammation, yet its implications in Zika virus (ZIKV) infection remain partially understood, especially in the context of ZIKV-induced congenital Zika syndrome (CZS) where both apoptosis and inflammation play pivotal roles. Our findings demonstrate that c-FLIP promotes ZIKV infection in placental cells and myeloid-derived macrophages, involving inflammation and caspase-8/3-mediated apoptosis. Moreover, our observations reveal that c-FLIP augments ZIKV infection in multiple tissues, including blood cell, spleen, uterus, testis, and the brain of mice. Notably, the partial deficiency of c-FLIP provides protection to embryos against ZIKV-induced CZS, accompanied by a reduction in caspase-3-mediated apoptosis. Additionally, we have found a distinctive parental effect of c-FLIP influencing ZIKV replication in fetal heads. In summary, our study reveals the critical role of c-FLIP as a positive regulator in caspase-8/3-mediated apoptosis during ZIKV infection, significantly contributing to the development of CZS.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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