Using synchronized brain rhythms to bias memory-guided decisions.
| Autor: | Stout JJ; Department of Psychological and Brain Sciences, University of Delaware, Newark, United States., George AE; Stony Brook University, Stony Brook, United States., Kim S; Department of Psychological and Brain Sciences, University of Delaware, Newark, United States., Hallock HL; Neuroscience Program, Lafayette College, Easton, United States., Griffin AL; Department of Psychological and Brain Sciences, University of Delaware, Newark, United States. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2024 Jul 22; Vol. 12. Date of Electronic Publication: 2024 Jul 22. |
| DOI: | 10.7554/eLife.92033 |
| Abstrakt: | Functional interactions between the prefrontal cortex and hippocampus, as revealed by strong oscillatory synchronization in the theta (6-11 Hz) frequency range, correlate with memory-guided decision-making. However, the degree to which this form of long-range synchronization influences memory-guided choice remains unclear. We developed a brain-machine interface that initiated task trials based on the magnitude of prefrontal-hippocampal theta synchronization, then measured choice outcomes. Trials initiated based on strong prefrontal-hippocampal theta synchrony were more likely to be correct compared to control trials on both working memory-dependent and -independent tasks. Prefrontal-thalamic neural interactions increased with prefrontal-hippocampal synchrony and optogenetic activation of the ventral midline thalamus primarily entrained prefrontal theta rhythms, but dynamically modulated synchrony. Together, our results show that prefrontal-hippocampal theta synchronization leads to a higher probability of a correct choice and strengthens prefrontal-thalamic dialogue. Our findings reveal new insights into the neural circuit dynamics underlying memory-guided choices and highlight a promising technique to potentiate cognitive processes or behavior via brain-machine interfacing. Competing Interests: JS, AG, SK, HH, AG No competing interests declared (© 2023, Stout et al.) |
| Databáze: | MEDLINE |
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