Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.

Autor: Hansel MC; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA., Rosenberg AM; Department of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY, 14642, USA., Kinkade CW; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA., Capurro C; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA., Rivera-Núñez Z; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA., Barrett ES; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. esb104@eohsi.rutgers.edu.; Department of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY, 14642, USA. esb104@eohsi.rutgers.edu.; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. esb104@eohsi.rutgers.edu.
Jazyk: angličtina
Zdroj: Current environmental health reports [Curr Environ Health Rep] 2024 Sep; Vol. 11 (3), pp. 356-379. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1007/s40572-024-00455-6
Abstrakt: Purpose of Review: Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.
Recent Findings: We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.
(© 2024. The Author(s).)
Databáze: MEDLINE
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