Advancing Kawasaki Disease Research in the Arab World: Scoping Literature Review Analysis with Emphasis on Giant Coronary Aneurysms.

Autor: Mohamed M; Faculty of Medicine, University of Montreal, Montreal, QC, Canada., Harahsheh A; Division of Cardiology Department of PediatricsSchool of Medicine & Health Sciences, Children's National Hospital, The George Washington University, Washington, USA., Choueiter N; Icahn School of Medicine at Mount Sinai, New York, USA., Agha HM; Pediatric Cardiology Division, Cairo University, Giza, Egypt., Alrabte H; Pediatric Cardiology Department, Tripoli Children Hospital, Tripoli, Libya., Abu Al-Saoud SY; Department of Pediatrics, Faculty of Medicine, Makassed Hospital, Al-Quds University, Jerusalem, Palestine., Al-Saloos H; Division of Cardiology, Sidra Medicine, Clinical Pediatrics, Weill Cornell Medicine, Ar-Rayyan, Qatar., Al Senaidi K; Division of Pediatric Cardiology, Sultan Qaboos University Hospital, Muscat, Oman., Alzyoud R; Pediatric Immunology, Allergy, and Rheumatology Division, Queen Rania Children's Hospital, Amman, Jordan., Al Awadhi Z; Al Jalila Children's Speciality Hospital, Dubai, United Arab Emirates., Belbouab R; Faculty of Medicine, Pediatric Department University Hospital, Mustapha Bacha Algiers, Algiers University, Algiers, Algeria., Bouayed K; Abderrahim Harouchi Mother-Child Hospital, CHU Ibn Rochd, Casablanca, Morocco., Bouaziz A; Headmaster of Children and Neonatal Department, Hôpital Régional Ben Arous, Ben Arous, Tunisia., El Ganzoury M; Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Fitouri Z; Division of Rheumatology, Emergency Department of Béchir Hamza Pediatric Hospital of Tunis, Tunis, Tunisia., Kotby A; Pediatric Cardiology Division, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ladj MS; Department of Pediatrics, Faculty of Medicine, Djillali Belkhenchir University Hospital, Algiers University, Algiers, Algeria., Bekkar MM; Pediatric Cardiology Unit, Department of Pediatrics, Faculty of Medicine, CHU Oran, Oran University, Oran, Algeria., Rugige N; Pediatric Cardiology Department, Benghazi Children Hospital, Benghazi University, Benghazi, Libya., Salih AF; Pediatric Cardiology Department/Children's Heart Hospital, Sulaimani College of Medicine-Sulaimani University, Al-Sulaimaniyah, Iraq., Sulaiman M; KidsHeart Medical Center, Abu-Dhabi, United Arab Emirates., Dahdah N; Division of Pediatric Cardiology, CHU Sainte-Justine, Montreal, Canada. Nagib.dahdah.med@ssss.gouv.qc.ca.
Jazyk: angličtina
Zdroj: Pediatric cardiology [Pediatr Cardiol] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1007/s00246-024-03589-4
Abstrakt: To evaluate giant aneurysms (GiAn) prevalence in Arab countries and examine contributing factors; and to review Kawasaki disease (KD) publication trends and collaborations among Arab nations. A scoping literature review was conducted to analyze the publications across the Arab world, spanning 16 countries from 1978 to 2023. The collected articles were a combination of database search with a call on Kawasaki Disease Arab Initiative (Kawarabi) members to share non-PubMed publications. Over 45 years, 50 articles originated from the Arab Countries with a 30% average annual growth rate in KD research output. Publications were evenly split between case reports (42%) and institutional series (52%). Research productivity lagged in developing nations with UAE, KSA and Egypt, contributed to 64% of total publications. Among 26 institutional series, 256 coronary artery aneurysms (CAA) from a total of 1264 KD cases were reported. Of those, 25 CAA were GiAn (prevalence 1.43% [range 0-12.5%]). The initial KD misdiagnosis rate was 4%, and incomplete KD (iKD) averaged 10.6%. Series (38.5%) that did not report iKD correlated with a higher prevalence of CAA, but not of GiAn. Longer fever duration emerged as a pivotal factor for GiAn (OR 5.06, 95%CI 1.51-17). This review unveils the research landscape of KD in the Arab world over 45 years. Initial misdiagnosis, untreated cases, delayed diagnosis and underreporting of iKD are contributing factors for an underestimated epidemiology, explaining the higher GiAn prevalence. This calls for strategic interventions to enhance KD research in these countries, aligning with Kawarabi's mission.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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