Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis.

Autor: Nagaharu K; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie Prefecture, Japan. keiki-nagaharu@med.mie-u.ac.jp.; Lund University Cancer Center, Lund University, Lund, Sweden. keiki-nagaharu@med.mie-u.ac.jp., Ohya E; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie Prefecture, Japan.; Department of Hematology, Matsusaka General Hospital, Matsusaka, Japan., Edahiro Y; Department of Hematology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan., Hashimoto Y; Department of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan., Ito T; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan., Gotoh A; Department of Hematology, Tokyo Medical University, Tokyo, Japan., Nakamae M; Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Kimura F; Division of Hematology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan., Koike M; Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan., Kirito K; Department of Hematology and Oncology, University of Yamanashi, Yamanashi, Japan., Wada H; Department of Hematology, Kawasaki Medical School, Okayama, Japan., Usuki K; Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan., Tanaka T; Department of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan., Mori T; Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.; Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan., Wakita S; Division of Hematology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan., Saito TI; Clinical Research Center, NHO Nagoya Medical Center, Aichi, Japan., Saito AM; Clinical Research Center, NHO Nagoya Medical Center, Aichi, Japan., Shimoda K; Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Kurokawa T; Department of Hematology, Toyama Red Cross Hospital, Toyama, Japan., Tomita A; Department of Hematology, Fujita Health University School of Medicine, Aichi, Japan., Kiyoi H; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Aichi, Japan., Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Matsumura I; Division of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka, Japan., Takenaka K; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan., Komatsu N; Department of Hematology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, Japan.; Laboratory for the Development of Therapies against MPN, Juntendo University Graduate School of Medicine, Tokyo, Japan.; Department of Advanced Hematology, Juntendo University Graduate School of Medicine, Tokyo, Japan.; PharmaEssentia Japan KK, Tokyo, Japan., Ohishi K; Department of Transfusion Medicine and Cell Therapy, Mie University Hospital, Mie Prefecture, Japan., Tawara I; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie Prefecture, Japan., Sugimoto Y; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie Prefecture, Japan.
Jazyk: angličtina
Zdroj: Annals of hematology [Ann Hematol] 2024 Sep; Vol. 103 (9), pp. 3535-3541. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1007/s00277-024-05898-3
Abstrakt: Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch's T-test. Statistical analyses were performed using the R statistical software. Thrombotic events were observed in 74 patients with ET. In multivariate analysis, only the neutrophil ratio was slightly but significantly higher for ET patients with thrombosis than for those without (p < 0.05). Of note, the absolute neutrophil count (aNeu) was considered a useful predictive tool for thrombosis among patients classified as low-risk according to the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia. Among PV patients, those with thrombosis showed significantly higher hematocrit and aNeu than did those without thrombosis. As a thrombosis-associated factor, the neutrophil ratio was slightly but significantly elevated in patients with ET. This myeloid skew might reflect a higher value of JAK2 V617F allelic frequency in patients with ET with thrombosis; this was not clarified in JSH-MPN-R18. Further accumulation of evidence, including genetic information for JAK2 and other passenger mutations, is warranted.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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