The 2022 PSOGI International Consensus on HIPEC Regimens for Peritoneal Malignancies: HIPEC Technologies.

Autor: Van der Speeten K; Department of Surgical Oncology, Ziekenhuis Oost-Limburg, Genk, Belgium. kurt.vanderspeeten@zol.be.; Faculty of Life Sciences, BIOMED Research Institute, University Hasselt, Hasselt, Belgium. kurt.vanderspeeten@zol.be., Kusamura S; Department of Surgical Oncology, PSM unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Villeneuve L; Department of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France., Piso P; Department of General and Visceral Surgery, Hospital Barmherzige Brüder, Regensburg, Germany., Verwaal VJ; Peritoneal Surface Malignancy and HIPEC Institute for Regional Sundhedforskning, Syddansk University, Odense, Sweden., González-Moreno S; MD Anderson Cancer Center, Calle de Arturo Soria 270, 28033, Madrid, Spain., Glehen O; Department of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France.
Jazyk: angličtina
Zdroj: Annals of surgical oncology [Ann Surg Oncol] 2024 Oct; Vol. 31 (10), pp. 7090-7110. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.1245/s10434-024-15513-4
Abstrakt: This manuscript reports the results of an international consensus on technologies of hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) performed with the following goals: To provide recommendations for the technological parameters to perform HIPEC. To identify the role of heat and its application forms in treating peritoneal metastases. To provide recommendations regarding the correct dosimetry of intraperitoneal chemotherapy drugs and their carrier solutions. To identify for each intraperitoneal chemotherapy regimen the best dosimetry and fractionation. To identify areas of future research pertaining to HIPEC technology and regimens. This consensus was performed by the Delphi technique and comprised two rounds of voting. In total, 96 of 102 eligible panelists replied to both Delphi rounds (94.1%) with a consensus of 39/51 questions on HIPEC technical aspects. Among the recommendations that met with the strongest consensus were those concerning the dose of HIPEC drug established in mg/m 2 , a target temperature of at least 42°C, and the use of at least three temperature probes to pursue hyperthermia. Ninety minutes as the ideal HIPEC duration seemed to make consensus. These results should be considered when designing new clinical trials in patients with peritoneal surface malignancies.
(© 2024. Society of Surgical Oncology.)
Databáze: MEDLINE
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