SARS-CoV-2 infection predisposes patients to coinfection with Staphylococcus aureus .

Autor:	Lubkin A; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Bernard-Raichon L; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., DuMont AL; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Valero Jimenez AM; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Putzel GG; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA., Gago J; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA., Zwack EE; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Olusanya O; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA., Boguslawski KM; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Dallari S; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Dyzenhaus S; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Herrmann C; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Ilmain JK; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Isom GL; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Pawline M; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Perault AI; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA., Perelman S; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Sause WE; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Shahi I; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., St John A; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Tierce R; Division of Comparative Medicine, New York University Langone Health, New York, New York, USA., Zheng X; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Zhou C; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Noval MG; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., O'Keeffe A; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Podkowik M; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA., Gonzales S; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Inglima K; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Desvignes L; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA.; High Containment Laboratories, Office of Science and Research, NYU Langone Health, New York, New York, USA., Hochman SE; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Thorpe LE; Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA., Pironti A; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA., Shopsin B; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Cadwell K; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Dittmann M; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.; Antimicrobial-Resistant Pathogens Program, Microbial Genomics Core Lab, New York University Langone Health, New York, New York, USA.
Jazyk:	angličtina
Zdroj:	MBio [mBio] 2024 Aug 14; Vol. 15 (8), pp. e0166724. Date of Electronic Publication: 2024 Jul 22.
DOI:	10.1128/mbio.01667-24
Abstrakt:	Severe COVID-19 has been associated with coinfections with bacterial and fungal pathogens. Notably, patients with COVID-19 who develop Staphylococcus aureus bacteremia exhibit higher rates of mortality than those infected with either pathogen alone. To understand this clinical scenario, we collected and examined S. aureus blood and respiratory isolates from a hospital in New York City during the early phase of the pandemic from both SARS-CoV-2+ and SARS-CoV-2- patients. Whole genome sequencing of these S. aureus isolates revealed broad phylogenetic diversity in both patient groups, suggesting that SARS-CoV-2 coinfection was not associated with a particular S. aureus lineage. Phenotypic characterization of the contemporary collection of S. aureus isolates from SARS-CoV-2+ and SARS-CoV-2- patients revealed no notable differences in several virulence traits examined. However, we noted a trend toward overrepresentation of S. aureus bloodstream strains with low cytotoxicity in the SARS-CoV-2+ group. We observed that patients coinfected with SARS-CoV-2 and S. aureus were more likely to die during the acute phase of infection when the coinfecting S. aureus strain exhibited high or low cytotoxicity. To further investigate the relationship between SARS-CoV-2 and S. aureus infections, we developed a murine coinfection model. These studies revealed that infection with SARS-CoV-2 renders mice susceptible to subsequent superinfection with low cytotoxicity S. aureus . Thus, SARS-CoV-2 infection sensitizes the host to coinfections, including S. aureus isolates with low intrinsic virulence. Importance: The COVID-19 pandemic has had an enormous impact on healthcare across the globe. Patients who were severely infected with SARS-CoV-2, the virus causing COVID-19, sometimes became infected with other pathogens, which is termed coinfection. If the coinfecting pathogen is the bacterium Staphylococcus aureus , there is an increased risk of patient death. We collected S. aureus strains that coinfected patients with SARS-CoV-2 to study the disease outcome caused by the interaction of these two important pathogens. We found that both in patients and in mice, coinfection with an S. aureus strain lacking toxicity resulted in more severe disease during the early phase of infection, compared with infection with either pathogen alone. Thus, SARS-CoV-2 infection can directly increase the severity of S. aureus infection. Competing Interests: V.J.T. has consulted for Janssen Research & Development, LLC, and has received honoraria from Genentech and Medimmune. He is also an inventor on patents and patent applications filed by New York University, which are currently under commercial license to Janssen Biotech Inc. Janssen Biotech Inc. had provided research funding and other payments associated with a licensing agreement. B.S. has consulted for Regeneron and MicroGenDx. K.C. has received research support from Pfizer, Takeda, Pacific Biosciences, Genentech, and AbbVie. R.T. completed a NYU-Regeneron postdoctoral training program in laboratory animal medicine.
Databáze:	MEDLINE
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